Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways

Isosinensetin alleviates estrogen deficiency-induced osteoporosis via suppressing ROS-mediated NF-κB/MAPK signaling pathways

The formation of osteoclasts and their hyperactive bone resorption are related to the aggregation of intracellular reactive oxygen species (ROS). Flavonoids, derived from plant active ingredients, can alleviate the symptoms of osteoporosis (OP). Isosinensetin (Iss) is a flavonoid with antioxidant ef...

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Bibliographic Details
Main Authors: Yiwu Qin, Dezhi Song, Shijie Liao, Junchun Chen, Minglian Xu, Yuangang Su, Haoyu Lian, Hui Peng, Linhua Wei, Kai Chen, Jiake Xu, Jinmin Zhao, Qian Liu
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Isosinensetin
ROS
NF-κB
MAPK
Osteoporosis
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222300135X

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