Utility of the succinate:fumarate ratio for assessing SDH dysfunction in different tumor types

Utility of the succinate:fumarate ratio for assessing SDH dysfunction in different tumor types

Objective: Mutations of genes encoding the four subunits of succinate dehydrogenase (SDH) have been associated with pheochromocytoma and paraganglioma (PPGLs), gastrointestinal stromal tumors (GISTs) and renal cell carcinomas (RCCs). These tumors have not been characterized in a way that reflects se...

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Detalles Bibliográficos
Main Authors:	Edward Kim, Michael JP. Wright, Loretta Sioson, Talia Novos, Anthony J. Gill, Diana E. Benn, Christopher White, Trisha Dwight, Roderick J. Clifton-Bligh
Formato:	Artigo
Idioma:	English
Publicado:	Elsevier 2017-03-01
Series:	Molecular Genetics and Metabolism Reports
Subjects:	Succinate dehydrogenase deficiency Mass spectrometry Pheochromocytoma and paraganglioma Gastrointestinal stromal tumor Renal cell carcinoma
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2214426916301288

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