Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, India
<b>Background:</b> Essential hypertension is a complex genetic disorder influenced by diverse environmental factors. Of the various physiological pathways affecting the homeostasis of blood pressure, the renin-angiotensin system (RAS) is known to play a critical role. Angiotensin-I conve...
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| Format: | Article |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Journal of Emergencies, Trauma and Shock |
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| Online Access: | http://www.onlinejets.org/article.asp?issn=0974-2700;year=2009;volume=2;issue=3;spage=150;epage=154;aulast=Gupta |
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| author | Gupta Sumeet Agrawal Bimal Goel Rajesh Sehajpal Prabodh |
| author_facet | Gupta Sumeet Agrawal Bimal Goel Rajesh Sehajpal Prabodh |
| author_sort | Gupta Sumeet |
| collection | DOAJ |
| description | <b>Background:</b> Essential hypertension is a complex genetic disorder influenced by diverse environmental factors. Of the various physiological pathways affecting the homeostasis of blood pressure, the renin-angiotensin system (RAS) is known to play a critical role. Angiotensin-I converting enzyme (ACE) is a significant component of RAS and an insertion/deletion (I/D) polymorphism in its gene has been implicated in predisposition to hypertension. <b>Objective:</b> The present study is aimed to determine the association, if any, of ACE I/D polymorphism with essential hypertension in a rural population of Haryana, India. <b>Materials and Methods:</b> The blood samples were collected from the patients visiting M. M. Institute of Medical Sciences, Mullana, Haryana. DNA from the patients (106) and control (110) specimens were isolated, amplified by PCR and analyzed employing agarose gel electrophoresis. <b>Results:</b> There was no significant difference in the distribution of DD, II and I/D genotypes of ACE polymorphism in essential hypertensive patients (28.8, 25.5, and 46.2%) and their ethnically matched normal control (24.5, 30, and 45.5), respectively. The two groups also presented with very similar allelic frequencies and were also found to be in Hardy-Weinberg equilibrium. <b>Conclusions:</b> The present study demonstrates that ACE I/D polymorphism is not a risk factor for essential hypertension in the hitherto unstudied rural population of Haryana. |
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| format | Article |
| id | doaj.art-840e4a5062d24000a1a4856357aec532 |
| institution | Directory Open Access Journal |
| issn | 0974-2700 |
| language | English |
| last_indexed | 2024-12-22T19:04:29Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Emergencies, Trauma and Shock |
| spelling | doaj.art-840e4a5062d24000a1a4856357aec5322022-12-21T18:15:51ZengWolters Kluwer Medknow PublicationsJournal of Emergencies, Trauma and Shock0974-27002009-01-0123150154Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, IndiaGupta SumeetAgrawal BimalGoel RajeshSehajpal Prabodh<b>Background:</b> Essential hypertension is a complex genetic disorder influenced by diverse environmental factors. Of the various physiological pathways affecting the homeostasis of blood pressure, the renin-angiotensin system (RAS) is known to play a critical role. Angiotensin-I converting enzyme (ACE) is a significant component of RAS and an insertion/deletion (I/D) polymorphism in its gene has been implicated in predisposition to hypertension. <b>Objective:</b> The present study is aimed to determine the association, if any, of ACE I/D polymorphism with essential hypertension in a rural population of Haryana, India. <b>Materials and Methods:</b> The blood samples were collected from the patients visiting M. M. Institute of Medical Sciences, Mullana, Haryana. DNA from the patients (106) and control (110) specimens were isolated, amplified by PCR and analyzed employing agarose gel electrophoresis. <b>Results:</b> There was no significant difference in the distribution of DD, II and I/D genotypes of ACE polymorphism in essential hypertensive patients (28.8, 25.5, and 46.2%) and their ethnically matched normal control (24.5, 30, and 45.5), respectively. The two groups also presented with very similar allelic frequencies and were also found to be in Hardy-Weinberg equilibrium. <b>Conclusions:</b> The present study demonstrates that ACE I/D polymorphism is not a risk factor for essential hypertension in the hitherto unstudied rural population of Haryana.http://www.onlinejets.org/article.asp?issn=0974-2700;year=2009;volume=2;issue=3;spage=150;epage=154;aulast=GuptaAngiotensin-I converting enzymeinsertion/deletion polymorphismessential hypertensionNorth Indian population |
| spellingShingle | Gupta Sumeet Agrawal Bimal Goel Rajesh Sehajpal Prabodh Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, India Journal of Emergencies, Trauma and Shock Angiotensin-I converting enzyme insertion/deletion polymorphism essential hypertension North Indian population |
| title | Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, India |
| title_full | Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, India |
| title_fullStr | Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, India |
| title_full_unstemmed | Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, India |
| title_short | Angiotensin-converting enzyme gene polymorphism in hypertensive rural population of Haryana, India |
| title_sort | angiotensin converting enzyme gene polymorphism in hypertensive rural population of haryana india |
| topic | Angiotensin-I converting enzyme insertion/deletion polymorphism essential hypertension North Indian population |
| url | http://www.onlinejets.org/article.asp?issn=0974-2700;year=2009;volume=2;issue=3;spage=150;epage=154;aulast=Gupta |
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