Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiatica
Centella asiatica is well known for its anti-inflammatory, anticancer, antioxidant, antimicrobial, analgesic, diuretic properties. Its hexane and methanol extracts were screened for the presence of phytoconstituents as well as their antibacterial and antioxidant activity. The phytochemical screenin...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Department of Physics, Mahendra Morang Adarsh Multiple Campus, Tribhuvan University
2021-02-01
|
| Series: | Bibechana |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/BIBECHANA/article/view/30760 |
| _version_ | 1797194057232941056 |
|---|---|
| author | Shanta Pokhrel Prabha Neupane |
| author_facet | Shanta Pokhrel Prabha Neupane |
| author_sort | Shanta Pokhrel |
| collection | DOAJ |
| description |
Centella asiatica is well known for its anti-inflammatory, anticancer, antioxidant, antimicrobial, analgesic, diuretic properties. Its hexane and methanol extracts were screened for the presence of phytoconstituents as well as their antibacterial and antioxidant activity. The phytochemical screening showed the presence of carbohydrate, glycosides, flavonoids, phenolic compound, alkaloids, and saponin. The methanol extract showed more effective antibacterial activity against salmonella typhi. Antioxidant activity of methanol extract was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity showed potent antioxidant activities with IC50 value 3.74 μg/mL slightly higher than standard ascorbic acid (IC50 = 2.576 μg/mL). The present study indicates that the tested plant can be an important source of antibacterial agents and recommends that the active phytoconstituents be isolated, identified, and screened individually for activities and also subjected further for in vivo and toxicological studies.
BIBECHANA 18 (2) (2021) 18-25
|
| first_indexed | 2024-04-24T05:50:13Z |
| format | Article |
| id | doaj.art-840eaf8955ef425990ea1c53f9ba2bd0 |
| institution | Directory Open Access Journal |
| issn | 2091-0762 2382-5340 |
| language | English |
| last_indexed | 2024-04-24T05:50:13Z |
| publishDate | 2021-02-01 |
| publisher | Department of Physics, Mahendra Morang Adarsh Multiple Campus, Tribhuvan University |
| record_format | Article |
| series | Bibechana |
| spelling | doaj.art-840eaf8955ef425990ea1c53f9ba2bd02024-04-23T13:05:06ZengDepartment of Physics, Mahendra Morang Adarsh Multiple Campus, Tribhuvan UniversityBibechana2091-07622382-53402021-02-0118210.3126/bibechana.v18i2.30760Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiaticaShanta Pokhrel0Prabha Neupane1Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu, NepalDepartment of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu Centella asiatica is well known for its anti-inflammatory, anticancer, antioxidant, antimicrobial, analgesic, diuretic properties. Its hexane and methanol extracts were screened for the presence of phytoconstituents as well as their antibacterial and antioxidant activity. The phytochemical screening showed the presence of carbohydrate, glycosides, flavonoids, phenolic compound, alkaloids, and saponin. The methanol extract showed more effective antibacterial activity against salmonella typhi. Antioxidant activity of methanol extract was evaluated by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity showed potent antioxidant activities with IC50 value 3.74 μg/mL slightly higher than standard ascorbic acid (IC50 = 2.576 μg/mL). The present study indicates that the tested plant can be an important source of antibacterial agents and recommends that the active phytoconstituents be isolated, identified, and screened individually for activities and also subjected further for in vivo and toxicological studies. BIBECHANA 18 (2) (2021) 18-25 https://www.nepjol.info/index.php/BIBECHANA/article/view/30760Antibacterial, Antioxidant, DPP, IC50, Phytochemical screening |
| spellingShingle | Shanta Pokhrel Prabha Neupane Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiatica Bibechana Antibacterial, Antioxidant, DPP, IC50, Phytochemical screening |
| title | Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiatica |
| title_full | Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiatica |
| title_fullStr | Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiatica |
| title_full_unstemmed | Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiatica |
| title_short | Phytochemical analysis, antioxidant and antibacterial efficacy of methanol and hexane extract of Centella asiatica |
| title_sort | phytochemical analysis antioxidant and antibacterial efficacy of methanol and hexane extract of centella asiatica |
| topic | Antibacterial, Antioxidant, DPP, IC50, Phytochemical screening |
| url | https://www.nepjol.info/index.php/BIBECHANA/article/view/30760 |
| work_keys_str_mv | AT shantapokhrel phytochemicalanalysisantioxidantandantibacterialefficacyofmethanolandhexaneextractofcentellaasiatica AT prabhaneupane phytochemicalanalysisantioxidantandantibacterialefficacyofmethanolandhexaneextractofcentellaasiatica |