Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians

Persistence of mRNA indicative of Plasmodium falciparum ring-stage parasites 42 days after artemisinin and non-artemisinin combination therapy in naturally infected Malians

Abstract Background Malaria control in sub-Saharan Africa relies upon prompt case management with artemisinin-based combination therapy (ACT). Ring-stage parasite mRNA, measured by sbp1 quantitative reverse-transcriptase PCR (qRT-PCR), was previously reported to persist after ACT treatment and hypot...

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Bibliographic Details
Main Authors: Almahamoudou Mahamar, Kjerstin Lanke, Wouter Graumans, Halimatou Diawara, Koualy Sanogo, Kalifa Diarra, Sidi Mohamed Niambele, Roly Gosling, Chris Drakeley, Ingrid Chen, Alassane Dicko, Teun Bousema, Michelle E. Roh
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Persistence
Artemisinin-based combination therapy
Dormancy
Recrudescence
Resistance
Online Access:https://doi.org/10.1186/s12936-020-03576-z

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