Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail
Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2018-03-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://apb.tbzmed.ac.ir/PDF/apb-8-39.pdf |
| _version_ | 1819026886182830080 |
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| author | Abed Ghavami Neda Roshanravan Shahriar Alipour Meisam Barati Behzad Mansoori Faezeh Ghalichi Elyas Nattagh- Eshtivan Alireza Ostadrahimi |
| author_facet | Abed Ghavami Neda Roshanravan Shahriar Alipour Meisam Barati Behzad Mansoori Faezeh Ghalichi Elyas Nattagh- Eshtivan Alireza Ostadrahimi |
| author_sort | Abed Ghavami |
| collection | DOAJ |
| description | Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/ d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch). We assessed glycemic and anthropometric indices, blood lipids and plasmatic level of miR-375 as well as KLF5 mRNA expression before and after the intervention. Results: Findings indicated that inulin supplementation significantly decreased fasting plasma glucose (FPG) in comparison to the placebo group (P<0.001). Also Intra-group and between group results showed that inulin supplementation resulted in significant decrease in KLF5 mRNA expression in peripheral blood mononuclear cells (PBMCs) (Fold change: 0.61± 0.11; P-value= 0.001) and significant increase in plasmatic level of miR-375 (Fold change: 3.75± 0.70; P-value=0.004). Conclusion: Considering the improvements of FPG level in diabetic patients, it seems that HP inulin supplementation may be beneficial in controlling diabetes via the expression of some genes. However, further studies are needed to achieve concise conclusions. |
| first_indexed | 2024-12-21T05:33:42Z |
| format | Article |
| id | doaj.art-840f93cf433340d08a82b6fbc95c3e6c |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-21T05:33:42Z |
| publishDate | 2018-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-840f93cf433340d08a82b6fbc95c3e6c2022-12-21T19:14:27ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082018-03-0181394710.15171/apb.2018.005apb-19400Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical TrailAbed Ghavami0Neda Roshanravan1Shahriar Alipour2Meisam Barati3Behzad Mansoori4Faezeh Ghalichi5Elyas Nattagh- Eshtivan6Alireza Ostadrahimi7Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Molecular Medicine, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Nutrition, School of Nutrition, Shahid beheshti University of Medical Sciences, Tehran, Iran.Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Nutrition, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/ d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch). We assessed glycemic and anthropometric indices, blood lipids and plasmatic level of miR-375 as well as KLF5 mRNA expression before and after the intervention. Results: Findings indicated that inulin supplementation significantly decreased fasting plasma glucose (FPG) in comparison to the placebo group (P<0.001). Also Intra-group and between group results showed that inulin supplementation resulted in significant decrease in KLF5 mRNA expression in peripheral blood mononuclear cells (PBMCs) (Fold change: 0.61± 0.11; P-value= 0.001) and significant increase in plasmatic level of miR-375 (Fold change: 3.75± 0.70; P-value=0.004). Conclusion: Considering the improvements of FPG level in diabetic patients, it seems that HP inulin supplementation may be beneficial in controlling diabetes via the expression of some genes. However, further studies are needed to achieve concise conclusions.http://apb.tbzmed.ac.ir/PDF/apb-8-39.pdfDiabetesInulinKLF5miR-375Fasting plasma glucose |
| spellingShingle | Abed Ghavami Neda Roshanravan Shahriar Alipour Meisam Barati Behzad Mansoori Faezeh Ghalichi Elyas Nattagh- Eshtivan Alireza Ostadrahimi Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail Advanced Pharmaceutical Bulletin Diabetes Inulin KLF5 miR-375 Fasting plasma glucose |
| title | Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail |
| title_full | Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail |
| title_fullStr | Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail |
| title_full_unstemmed | Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail |
| title_short | Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail |
| title_sort | assessing the effect of high performance inulin supplementation via klf5 mrna expression in adults with type 2 diabetes a randomized placebo controlled clinical trail |
| topic | Diabetes Inulin KLF5 miR-375 Fasting plasma glucose |
| url | http://apb.tbzmed.ac.ir/PDF/apb-8-39.pdf |
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