Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires

Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires

Processes that define immunoglobulin repertoires are commonly presumed to be the same for all murine B cells. However, studies here that couple high-dimensional FACS sorting with large-scale quantitative IgH deep-sequencing demonstrate that B-1a IgH repertoire differs dramatically from the follicula...

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Bibliographic Details
Main Authors: Yang Yang, Chunlin Wang, Qunying Yang, Aaron B Kantor, Hiutung Chu, Eliver EB Ghosn, Guang Qin, Sarkis K Mazmanian, Jian Han, Leonore A Herzenberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
V(D)J
diversify
IgH
Online Access:https://elifesciences.org/articles/09083

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