Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study
It is unknown whether neurological symptoms are associated with brain injury after SARS-CoV-2 infections and whether brain injury and related symptoms also emerge in Long-COVID patients. Biomarkers such as serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) can be used...
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/13/2167 |
| _version_ | 1797591908901453824 |
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| author | Julia Telser Kirsten Grossmann Ornella C. Weideli Dorothea Hillmann Stefanie Aeschbacher Niklas Wohlwend Laura Velez Jens Kuhle Aleksandra Maleska Pascal Benkert Corina Risch David Conen Martin Risch Lorenz Risch |
| author_facet | Julia Telser Kirsten Grossmann Ornella C. Weideli Dorothea Hillmann Stefanie Aeschbacher Niklas Wohlwend Laura Velez Jens Kuhle Aleksandra Maleska Pascal Benkert Corina Risch David Conen Martin Risch Lorenz Risch |
| author_sort | Julia Telser |
| collection | DOAJ |
| description | It is unknown whether neurological symptoms are associated with brain injury after SARS-CoV-2 infections and whether brain injury and related symptoms also emerge in Long-COVID patients. Biomarkers such as serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) can be used to elucidate neuro-axonal and astroglial injuries. We investigated whether these biomarkers are associated with COVID-19 infection status, associated symptoms and Long-COVID. From 146 individuals of the general population with a post-acute, mild-to-moderate SARS-CoV-2 infection, sNfL and sGFAP were measured before, during and after (five and ten months) the infection. Individual symptoms and Long-COVID status were assessed using questionnaires. Neurological associated symptoms were described for individuals after a mild and moderate COVID-19 infection; however, sNfL (<i>p</i> = 0.74) and sGFAP (<i>p</i> = 0.24) did not change and were not associated with headache (<i>p</i> = 0.51), fatigue (<i>p</i> = 0.93), anosmia (<i>p</i> = 0.77) or ageusia (<i>p</i> = 0.47). In Long-COVID patients, sGFAP (<i>p</i> = 0.038), but not sNfL (<i>p</i> = 0.58), significantly increased but was not associated with neurological associated symptoms. Long-COVID status, but not post-acute SARS-CoV-2 infections, may be associated with astroglial injury/activation, even if neurological associated symptoms were not correlated. |
| first_indexed | 2024-03-11T01:44:06Z |
| format | Article |
| id | doaj.art-841415250f7f4633900078bd160412d4 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T01:44:06Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-841415250f7f4633900078bd160412d42023-11-18T16:20:56ZengMDPI AGDiagnostics2075-44182023-06-011313216710.3390/diagnostics13132167Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP StudyJulia Telser0Kirsten Grossmann1Ornella C. Weideli2Dorothea Hillmann3Stefanie Aeschbacher4Niklas Wohlwend5Laura Velez6Jens Kuhle7Aleksandra Maleska8Pascal Benkert9Corina Risch10David Conen11Martin Risch12Lorenz Risch13Dr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinDr. Risch Medical Laboratory, 9470 Buchs, SwitzerlandDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinNeurologic Clinic and Policlinic, MS Center and Research Center of Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, 4031 Basel, SwitzerlandNeurologic Clinic and Policlinic, MS Center and Research Center of Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, 4031 Basel, SwitzerlandNeurologic Clinic and Policlinic, MS Center and Research Center of Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel, University of Basel, 4031 Basel, SwitzerlandDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinPopulation Health Research Institute, McMaster University, Hamilton, ON L8L 2X2, CanadaDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinDr. Risch Medical Laboratory, 9490 Vaduz, LiechtensteinIt is unknown whether neurological symptoms are associated with brain injury after SARS-CoV-2 infections and whether brain injury and related symptoms also emerge in Long-COVID patients. Biomarkers such as serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) can be used to elucidate neuro-axonal and astroglial injuries. We investigated whether these biomarkers are associated with COVID-19 infection status, associated symptoms and Long-COVID. From 146 individuals of the general population with a post-acute, mild-to-moderate SARS-CoV-2 infection, sNfL and sGFAP were measured before, during and after (five and ten months) the infection. Individual symptoms and Long-COVID status were assessed using questionnaires. Neurological associated symptoms were described for individuals after a mild and moderate COVID-19 infection; however, sNfL (<i>p</i> = 0.74) and sGFAP (<i>p</i> = 0.24) did not change and were not associated with headache (<i>p</i> = 0.51), fatigue (<i>p</i> = 0.93), anosmia (<i>p</i> = 0.77) or ageusia (<i>p</i> = 0.47). In Long-COVID patients, sGFAP (<i>p</i> = 0.038), but not sNfL (<i>p</i> = 0.58), significantly increased but was not associated with neurological associated symptoms. Long-COVID status, but not post-acute SARS-CoV-2 infections, may be associated with astroglial injury/activation, even if neurological associated symptoms were not correlated.https://www.mdpi.com/2075-4418/13/13/2167COVID-19SARS-CoV-2serum biomarkerglial fibrillary acidic proteinneurofilament light chainGFAP |
| spellingShingle | Julia Telser Kirsten Grossmann Ornella C. Weideli Dorothea Hillmann Stefanie Aeschbacher Niklas Wohlwend Laura Velez Jens Kuhle Aleksandra Maleska Pascal Benkert Corina Risch David Conen Martin Risch Lorenz Risch Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study Diagnostics COVID-19 SARS-CoV-2 serum biomarker glial fibrillary acidic protein neurofilament light chain GFAP |
| title | Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study |
| title_full | Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study |
| title_fullStr | Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study |
| title_full_unstemmed | Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study |
| title_short | Concentrations of Serum Brain Injury Biomarkers Following SARS-CoV-2 Infection in Individuals with and without Long-COVID—Results from the Prospective Population-Based COVI-GAPP Study |
| title_sort | concentrations of serum brain injury biomarkers following sars cov 2 infection in individuals with and without long covid results from the prospective population based covi gapp study |
| topic | COVID-19 SARS-CoV-2 serum biomarker glial fibrillary acidic protein neurofilament light chain GFAP |
| url | https://www.mdpi.com/2075-4418/13/13/2167 |
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