Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction
The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behaviour. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (wit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00214/full |
| _version_ | 1818656410027687936 |
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| author | Charlotte Rachael Flavell Elliot eLambert Boyer D Winters Timothy W Bredy |
| author_facet | Charlotte Rachael Flavell Elliot eLambert Boyer D Winters Timothy W Bredy |
| author_sort | Charlotte Rachael Flavell |
| collection | DOAJ |
| description | The extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behaviour. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in it’s destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following it’s reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace. |
| first_indexed | 2024-12-17T03:25:08Z |
| format | Article |
| id | doaj.art-8415fe12ac054bd4a6f00a5a51e89af4 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-17T03:25:08Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-8415fe12ac054bd4a6f00a5a51e89af42022-12-21T22:05:24ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532013-12-01710.3389/fnbeh.2013.0021469151Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinctionCharlotte Rachael Flavell0Elliot eLambert1Boyer D Winters2Timothy W Bredy3Queensland Brain InstituteQueensland Brain InstituteUniversity of GuelphQueensland Brain InstituteThe extinction of learned associations has traditionally been considered to involve new learning, which competes with the original memory for control over behaviour. However, a recent resurgence of interest in reactivation-dependent amnesia has revealed that the retrieval of fear-related memory (with what is essentially a brief extinction session) can result in it’s destabilization. This review discusses some of the cellular and molecular mechanisms that are involved in the destabilization of a memory following it’s reactivation and/or extinction, and investigates the evidence that extinction may involve both new learning as well as a partial destabilization-induced erasure of the original memory trace.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00214/fullCalcineurinDendritic SpinesNMDAnon-coding RNAextinctionAMPA |
| spellingShingle | Charlotte Rachael Flavell Elliot eLambert Boyer D Winters Timothy W Bredy Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction Frontiers in Behavioral Neuroscience Calcineurin Dendritic Spines NMDA non-coding RNA extinction AMPA |
| title | Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction |
| title_full | Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction |
| title_fullStr | Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction |
| title_full_unstemmed | Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction |
| title_short | Mechanisms governing the reactivation-dependent destabilization of memories and their role in extinction |
| title_sort | mechanisms governing the reactivation dependent destabilization of memories and their role in extinction |
| topic | Calcineurin Dendritic Spines NMDA non-coding RNA extinction AMPA |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00214/full |
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