Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer
Abstract Background Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. According to the research of circular RNAs in the CRC field, compared with linear RNAs, circular RNAs are a special type of noncoding RNA that are covalently closed circular structures, whi...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.4398 |
| _version_ | 1819174257673895936 |
|---|---|
| author | Shunhao Zhang Jing Sun Minqi Gu Guihua Wang Xudong Wang |
| author_facet | Shunhao Zhang Jing Sun Minqi Gu Guihua Wang Xudong Wang |
| author_sort | Shunhao Zhang |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. According to the research of circular RNAs in the CRC field, compared with linear RNAs, circular RNAs are a special type of noncoding RNA that are covalently closed circular structures, which have no 5' cap structure and 3' polyA tail and are not affected by RNA exonuclease and actinomycin D. Biological functions Notably, circular RNAs have a high degree of stability and potential effect on gene regulation. Meanwhile, circular RNAs are involved in the sponge action of microRNAs and mediate protein translation and direct binding, alternative splicing, and histone modification. Relationships with CRC Studies have shown that circular RNAs are related to the proliferation, invasion, recurrence, metastasis, ferroptosis, apoptosis, and chemotherapy resistance of CRC. Conclusions This article provides a brief review based on the source, structural characteristics, mechanisms, biological functions of circular RNAs, and the relationships between CRC. |
| first_indexed | 2024-12-22T20:36:06Z |
| format | Article |
| id | doaj.art-8417d9ae049543c097f84a6f6da35326 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-22T20:36:06Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-8417d9ae049543c097f84a6f6da353262022-12-21T18:13:27ZengWileyCancer Medicine2045-76342021-12-0110248725874010.1002/cam4.4398Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancerShunhao Zhang0Jing Sun1Minqi Gu2Guihua Wang3Xudong Wang4Graduate School of Nantong University Nantong ChinaGraduate School of Nantong University Nantong ChinaGraduate School of Nantong University Nantong ChinaDepartment of Laboratory Medicine Affiliated Hospital of Nantong University Nantong ChinaDepartment of Laboratory Medicine Affiliated Hospital of Nantong University Nantong ChinaAbstract Background Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. According to the research of circular RNAs in the CRC field, compared with linear RNAs, circular RNAs are a special type of noncoding RNA that are covalently closed circular structures, which have no 5' cap structure and 3' polyA tail and are not affected by RNA exonuclease and actinomycin D. Biological functions Notably, circular RNAs have a high degree of stability and potential effect on gene regulation. Meanwhile, circular RNAs are involved in the sponge action of microRNAs and mediate protein translation and direct binding, alternative splicing, and histone modification. Relationships with CRC Studies have shown that circular RNAs are related to the proliferation, invasion, recurrence, metastasis, ferroptosis, apoptosis, and chemotherapy resistance of CRC. Conclusions This article provides a brief review based on the source, structural characteristics, mechanisms, biological functions of circular RNAs, and the relationships between CRC.https://doi.org/10.1002/cam4.4398biomarkercancer stem cellcircular RNAcolorectal cancerrecurrence and metastasistherapeutic target |
| spellingShingle | Shunhao Zhang Jing Sun Minqi Gu Guihua Wang Xudong Wang Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer Cancer Medicine biomarker cancer stem cell circular RNA colorectal cancer recurrence and metastasis therapeutic target |
| title | Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer |
| title_full | Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer |
| title_fullStr | Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer |
| title_full_unstemmed | Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer |
| title_short | Circular RNA: A promising new star for the diagnosis and treatment of colorectal cancer |
| title_sort | circular rna a promising new star for the diagnosis and treatment of colorectal cancer |
| topic | biomarker cancer stem cell circular RNA colorectal cancer recurrence and metastasis therapeutic target |
| url | https://doi.org/10.1002/cam4.4398 |
| work_keys_str_mv | AT shunhaozhang circularrnaapromisingnewstarforthediagnosisandtreatmentofcolorectalcancer AT jingsun circularrnaapromisingnewstarforthediagnosisandtreatmentofcolorectalcancer AT minqigu circularrnaapromisingnewstarforthediagnosisandtreatmentofcolorectalcancer AT guihuawang circularrnaapromisingnewstarforthediagnosisandtreatmentofcolorectalcancer AT xudongwang circularrnaapromisingnewstarforthediagnosisandtreatmentofcolorectalcancer |