Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction
<b>Background:</b> Insufficient sleep is a serious public health problem in modern society. It leads to increased risk of chronic diseases, and it has been frequently associated with cellular oxidative damage and widespread low-grade inflammation. Probiotics have been attracting increasi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/6/1518 |
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| author | Yadong Zheng Luyan Zhang Laura Bonfili Luisa de Vivo Anna Maria Eleuteri Michele Bellesi |
| author_facet | Yadong Zheng Luyan Zhang Laura Bonfili Luisa de Vivo Anna Maria Eleuteri Michele Bellesi |
| author_sort | Yadong Zheng |
| collection | DOAJ |
| description | <b>Background:</b> Insufficient sleep is a serious public health problem in modern society. It leads to increased risk of chronic diseases, and it has been frequently associated with cellular oxidative damage and widespread low-grade inflammation. Probiotics have been attracting increasing interest recently for their antioxidant and anti-inflammatory properties. Here, we tested the ability of probiotics to contrast oxidative stress and inflammation induced by sleep loss. <b>Methods:</b> We administered a multi-strain probiotic formulation (SLAB51) or water to normal sleeping mice and to mice exposed to 7 days of chronic sleep restriction (CSR). We quantified protein, lipid, and DNA oxidation as well as levels of gut–brain axis hormones and pro and anti-inflammatory cytokines in the brain and plasma. Furthermore, we carried out an evaluation of microglia morphology and density in the mouse cerebral cortex. <b>Results:</b> We found that CSR induced oxidative stress and inflammation and altered gut–brain axis hormones. SLAB51 oral administration boosted the antioxidant capacity of the brain, thus limiting the oxidative damage provoked by loss of sleep. Moreover, it positively regulated gut–brain axis hormones and reduced peripheral and brain inflammation induced by CSR. <b>Conclusions:</b> Probiotic supplementation can be a possible strategy to counteract oxidative stress and inflammation promoted by sleep loss. |
| first_indexed | 2024-03-11T06:04:16Z |
| format | Article |
| id | doaj.art-84181adf6a9c4e4b839a063f6095a83f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T06:04:16Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-84181adf6a9c4e4b839a063f6095a83f2023-11-17T13:06:54ZengMDPI AGNutrients2072-66432023-03-01156151810.3390/nu15061518Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep RestrictionYadong Zheng0Luyan Zhang1Laura Bonfili2Luisa de Vivo3Anna Maria Eleuteri4Michele Bellesi5School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, MC, ItalyCenter for Neuroscience, University of Camerino, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, MC, ItalySchool of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, MC, Italy<b>Background:</b> Insufficient sleep is a serious public health problem in modern society. It leads to increased risk of chronic diseases, and it has been frequently associated with cellular oxidative damage and widespread low-grade inflammation. Probiotics have been attracting increasing interest recently for their antioxidant and anti-inflammatory properties. Here, we tested the ability of probiotics to contrast oxidative stress and inflammation induced by sleep loss. <b>Methods:</b> We administered a multi-strain probiotic formulation (SLAB51) or water to normal sleeping mice and to mice exposed to 7 days of chronic sleep restriction (CSR). We quantified protein, lipid, and DNA oxidation as well as levels of gut–brain axis hormones and pro and anti-inflammatory cytokines in the brain and plasma. Furthermore, we carried out an evaluation of microglia morphology and density in the mouse cerebral cortex. <b>Results:</b> We found that CSR induced oxidative stress and inflammation and altered gut–brain axis hormones. SLAB51 oral administration boosted the antioxidant capacity of the brain, thus limiting the oxidative damage provoked by loss of sleep. Moreover, it positively regulated gut–brain axis hormones and reduced peripheral and brain inflammation induced by CSR. <b>Conclusions:</b> Probiotic supplementation can be a possible strategy to counteract oxidative stress and inflammation promoted by sleep loss.https://www.mdpi.com/2072-6643/15/6/1518probioticssleep deprivationinflammationoxidative stressmicroglia |
| spellingShingle | Yadong Zheng Luyan Zhang Laura Bonfili Luisa de Vivo Anna Maria Eleuteri Michele Bellesi Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction Nutrients probiotics sleep deprivation inflammation oxidative stress microglia |
| title | Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction |
| title_full | Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction |
| title_fullStr | Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction |
| title_full_unstemmed | Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction |
| title_short | Probiotics Supplementation Attenuates Inflammation and Oxidative Stress Induced by Chronic Sleep Restriction |
| title_sort | probiotics supplementation attenuates inflammation and oxidative stress induced by chronic sleep restriction |
| topic | probiotics sleep deprivation inflammation oxidative stress microglia |
| url | https://www.mdpi.com/2072-6643/15/6/1518 |
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