Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells.

Protein arginine methylation is more prone to inhibition by S-adenosylhomocysteine than DNA methylation in vascular endothelial cells.

Methyltransferases use S-adenosylmethionine (AdoMet) as methyl group donor, forming S-adenosylhomocysteine (AdoHcy) and methylated substrates, including DNA and proteins. AdoHcy inhibits most methyltransferases. Accumulation of intracellular AdoHcy secondary to Hcy elevation elicits global DNA hypom...

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Bibliographic Details
Main Authors: Ruben Esse, Monica S Rocha, Madalena Barroso, Cristina Florindo, Tom Teerlink, Robert M Kok, Yvo M Smulders, Isabel Rivera, Paula Leandro, Pieter Koolwijk, Rita Castro, Henk J Blom, Isabel Tavares de Almeida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3568140?pdf=render

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