Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses

Inhibitor of Hyaluronic Acid Synthesis 4-Methylumbelliferone as an Anti-Inflammatory Modulator of LPS-Mediated Astrocyte Responses

Astrocytes are glial cells that play an important role in neuroinflammation. Astrocytes respond to many pro-inflammatory stimuli, including lipopolysaccharide (LPS), an agonist of Toll-like receptor 4 (TLR4). Regulatory specificities of inflammatory signaling pathways are still largely unknown due t...

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Bibliographic Details
Main Authors: Dmitry V. Chistyakov, Arina I. Nikolskaya, Sergei V. Goriainov, Alina A. Astakhova, Marina G. Sergeeva
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
astrocytes
4-methylumbelliferone (4-MU)
cyclooxygenase (COX)
hyaluronic acid
interleukin 10 (IL-10)
interleukin 6 (IL-6)
Online Access:https://www.mdpi.com/1422-0067/21/21/8203

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