Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma

Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) developed in fibrotic liver does not respond well to immunotherapy, mainly due to the stromal microenvironment and the fibrosis-related immunosuppressive factors. The characteristic of liver sinusoidal endothelial cells (LSECs) in contributing to fi...

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Bibliographic Details
Main Authors: Zhuo Yu, Jianfeng Guo, Yun Liu, Menglin Wang, Zhengsheng Liu, Yueqiu Gao, Leaf Huang
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Nanobiotechnology
Subjects:
Liver sinusoidal endothelial cells
Hepatocellular carcinoma
Simvastatin
Nanoparticles
Tumor microenvironment remodeling
Online Access:https://doi.org/10.1186/s12951-021-01205-8

Internet

https://doi.org/10.1186/s12951-021-01205-8

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