N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition

N7-Methylation of the Coronavirus RNA Cap Is Required for Maximal Virulence by Preventing Innate Immune Recognition

ABSTRACT The ongoing coronavirus (CoV) disease 2019 (COVID-19) pandemic caused by infection with severe acute respiratory syndrome CoV 2 (SARS-CoV-2) is associated with substantial morbidity and mortality. Understanding the immunological and pathological processes of coronavirus diseases is crucial...

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Bibliographic Details
Main Authors: Ruangang Pan, Eveline Kindler, Liu Cao, Yu Zhou, Zhen Zhang, Qianyun Liu, Nadine Ebert, Roland Züst, Ying Sun, Alexander E. Gorbalenya, Stanley Perlman, Volker Thiel, Yu Chen, Deyin Guo
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:mBio
Subjects:
coronavirus
nonstructural protein 14 (nsp14)
RNA cap structure
N7-methylation
type I interferon
SARS-CoV-2
Online Access:https://journals.asm.org/doi/10.1128/mbio.03662-21

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