4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine
A new hybrid compound, 4-(3-phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine <b>3</b>, with promising biological activity was efficiently synthesized by the reaction of 3-phenyl-1-(thieno[3,2-<i>d</i>]pyr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Molbank |
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| Online Access: | https://www.mdpi.com/1422-8599/2020/2/M1136 |
| _version_ | 1797567740684271616 |
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| author | Eun Sun Noh Sung Min Kim Yang-Heon Song |
| author_facet | Eun Sun Noh Sung Min Kim Yang-Heon Song |
| author_sort | Eun Sun Noh |
| collection | DOAJ |
| description | A new hybrid compound, 4-(3-phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine <b>3</b>, with promising biological activity was efficiently synthesized by the reaction of 3-phenyl-1-(thieno[3,2-<i>d</i>]pyrimidin-4-yl)-1<i>H</i>-pyrazol-5-amine with Vilsmeier–Haack reagent and subsequent treatment with ammonium carbonate. The structure of the synthesized compound was fully characterized by <sup>1</sup>H-, <sup>13</sup>C-NMR, IR spectroscopy, mass-spectrometry and elemental analysis. |
| first_indexed | 2024-03-10T19:46:46Z |
| format | Article |
| id | doaj.art-841d028468ea46d681735e3dd0aed093 |
| institution | Directory Open Access Journal |
| issn | 1422-8599 |
| language | English |
| last_indexed | 2024-03-10T19:46:46Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molbank |
| spelling | doaj.art-841d028468ea46d681735e3dd0aed0932023-11-20T00:45:59ZengMDPI AGMolbank1422-85992020-05-0120202M113610.3390/M11364-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidineEun Sun Noh0Sung Min Kim1Yang-Heon Song2Department of Chemistry, Mokwon University, Doanbuk-Ro 88, Daejeon 35349, KoreaDepartment of Chemistry, Mokwon University, Doanbuk-Ro 88, Daejeon 35349, KoreaDepartment of Chemistry, Mokwon University, Doanbuk-Ro 88, Daejeon 35349, KoreaA new hybrid compound, 4-(3-phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine <b>3</b>, with promising biological activity was efficiently synthesized by the reaction of 3-phenyl-1-(thieno[3,2-<i>d</i>]pyrimidin-4-yl)-1<i>H</i>-pyrazol-5-amine with Vilsmeier–Haack reagent and subsequent treatment with ammonium carbonate. The structure of the synthesized compound was fully characterized by <sup>1</sup>H-, <sup>13</sup>C-NMR, IR spectroscopy, mass-spectrometry and elemental analysis.https://www.mdpi.com/1422-8599/2020/2/M1136thieno[3,2-<i>d</i>]pyrimidinepyrazolo[3,4-<i>d</i>]pyrimidineVilsmeier–Haack reagent |
| spellingShingle | Eun Sun Noh Sung Min Kim Yang-Heon Song 4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine Molbank thieno[3,2-<i>d</i>]pyrimidine pyrazolo[3,4-<i>d</i>]pyrimidine Vilsmeier–Haack reagent |
| title | 4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine |
| title_full | 4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine |
| title_fullStr | 4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine |
| title_full_unstemmed | 4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine |
| title_short | 4-(3-Phenyl-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-1-yl)thieno[3,2-<i>d</i>]pyrimidine |
| title_sort | 4 3 phenyl 1 i h i pyrazolo 3 4 i d i pyrimidin 1 yl thieno 3 2 i d i pyrimidine |
| topic | thieno[3,2-<i>d</i>]pyrimidine pyrazolo[3,4-<i>d</i>]pyrimidine Vilsmeier–Haack reagent |
| url | https://www.mdpi.com/1422-8599/2020/2/M1136 |
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