Nitric oxide-induced lipophagic defects contribute to testosterone deficiency in rats with spinal cord injury

Nitric oxide-induced lipophagic defects contribute to testosterone deficiency in rats with spinal cord injury

IntroductionMales with acute spinal cord injury (SCI) frequently exhibit testosterone deficiency and reproductive dysfunction. While such incidence rates are high in chronic patients, the underlying mechanisms remain elusive.Methods and resultsHerein, we generated a rat SCI model, which recapitulate...

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Bibliographic Details
Main Authors: Yuge Zhuang, Wenyuan Liu, Feilong Chen, Minyu Xie, Hanbin Zhang, Zicong Huang, Xiaoyuan Zhang, Jinsheng Liu, Ke Ma, Hongrui Feng, Shipeng Ruan, Jing He, Wansong Zhang, Feng Zou, Xiangjin Kang, Yong Fan, Guofei Zhang, Zhenguo Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Endocrinology
Subjects:
spinal cord injury
Leydig cells
nitric oxide
lipophagy
testosterone
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1360499/full

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