The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight.
<h4>Background</h4>Complications of overweight amplify with age, and irreversible damage already exists in young persons. Identifying the most sensitive age interval(s) for adult overweight is relevant for primary prevention. The aim of the study was to assess the relative contribution o...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-02-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20161800/pdf/?tool=EBI |
| _version_ | 1818722242686615552 |
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| author | Marlou L A De Kroon Carry M Renders Jacobus P Van Wouwe Stef Van Buuren Remy A Hirasing |
| author_facet | Marlou L A De Kroon Carry M Renders Jacobus P Van Wouwe Stef Van Buuren Remy A Hirasing |
| author_sort | Marlou L A De Kroon |
| collection | DOAJ |
| description | <h4>Background</h4>Complications of overweight amplify with age, and irreversible damage already exists in young persons. Identifying the most sensitive age interval(s) for adult overweight is relevant for primary prevention. The aim of the study was to assess the relative contribution of body mass index (BMI) changes between 0 and 18 years to adult overweight, and to identify the earliest critical growth period.<h4>Methods and findings</h4>Data from 762 subjects in the Terneuzen Birth Cohort with an average of 21 growth measurements per subject from birth until 18 years were used. The main outcome measure was the BMI standard deviation score (SDS) at young adulthood. For each subject BMI SDS was fitted by a piecewise linear model at eight different ages and correlated to adult BMI SDS. The age intervals in between are considered critical according to three criteria, tested by respectively Students' t-tests, multiple linear regression analyses and Pearson's correlation tests. In the age intervals 4 months(m) -1 year(y), 2-6 y, 6-10 y and 10-18 y the BMI SDS change differs between adults with and without overweight (P<or=0.001). The age intervals 2-6 y and 10-18 y also meet the second criterion, implying that the BMI change during this period has a predictive value for adult BMI SDS in addition to BMI SDS at the end of the period. The largest rise in correlation between estimated BMI SDS and measured adult BMI SDS occurs during the period 2-6 y (from 0.36 to 0.63), which results in a high sensitivity (0.6) and specificity (0.8) by the age of 6 y.<h4>Conclusions/significance</h4>The age interval from 2 y to 6 y is the earliest and most critical growth period for adult overweight. Therefore, primary prevention of adult overweight seems most likely to be successful if targeted at this specific age interval. By identifying those with an upwards centile crossing between 2 and 6 years, the development towards adult overweight might be reversed. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T20:51:31Z |
| publishDate | 2010-02-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-841d57db4104495b81595736d4df75572022-12-21T21:33:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-02-0152e915510.1371/journal.pone.0009155The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight.Marlou L A De KroonCarry M RendersJacobus P Van WouweStef Van BuurenRemy A Hirasing<h4>Background</h4>Complications of overweight amplify with age, and irreversible damage already exists in young persons. Identifying the most sensitive age interval(s) for adult overweight is relevant for primary prevention. The aim of the study was to assess the relative contribution of body mass index (BMI) changes between 0 and 18 years to adult overweight, and to identify the earliest critical growth period.<h4>Methods and findings</h4>Data from 762 subjects in the Terneuzen Birth Cohort with an average of 21 growth measurements per subject from birth until 18 years were used. The main outcome measure was the BMI standard deviation score (SDS) at young adulthood. For each subject BMI SDS was fitted by a piecewise linear model at eight different ages and correlated to adult BMI SDS. The age intervals in between are considered critical according to three criteria, tested by respectively Students' t-tests, multiple linear regression analyses and Pearson's correlation tests. In the age intervals 4 months(m) -1 year(y), 2-6 y, 6-10 y and 10-18 y the BMI SDS change differs between adults with and without overweight (P<or=0.001). The age intervals 2-6 y and 10-18 y also meet the second criterion, implying that the BMI change during this period has a predictive value for adult BMI SDS in addition to BMI SDS at the end of the period. The largest rise in correlation between estimated BMI SDS and measured adult BMI SDS occurs during the period 2-6 y (from 0.36 to 0.63), which results in a high sensitivity (0.6) and specificity (0.8) by the age of 6 y.<h4>Conclusions/significance</h4>The age interval from 2 y to 6 y is the earliest and most critical growth period for adult overweight. Therefore, primary prevention of adult overweight seems most likely to be successful if targeted at this specific age interval. By identifying those with an upwards centile crossing between 2 and 6 years, the development towards adult overweight might be reversed.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20161800/pdf/?tool=EBI |
| spellingShingle | Marlou L A De Kroon Carry M Renders Jacobus P Van Wouwe Stef Van Buuren Remy A Hirasing The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight. PLoS ONE |
| title | The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight. |
| title_full | The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight. |
| title_fullStr | The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight. |
| title_full_unstemmed | The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight. |
| title_short | The Terneuzen birth cohort: BMI changes between 2 and 6 years correlate strongest with adult overweight. |
| title_sort | terneuzen birth cohort bmi changes between 2 and 6 years correlate strongest with adult overweight |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20161800/pdf/?tool=EBI |
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