The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression
The aim of this study was to determine whether depression was affect on bone loss in postmenopausal osteoporotic (PMO) women and response to calcitriol treatment in this patients. Seventy two females (mean age 65 ± 6.9) were included in this study. Out of these patients, 27 (37.5%) had depression, 4...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2003-12-01
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| Series: | Türk Osteoporoz Dergisi |
| Subjects: | |
| Online Access: | http://www.turkosteoporozdergisi.org/article_4190/The-Evaluation-Of-Efficacy-Of-Calcitriol-On-Bone-Mineral-Density-Pain-And-Quality-Of-Life-In-Postmenopausal-Osteoporotic-Patients-With-Or-Without-Depression |
| _version_ | 1797910983975370752 |
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| author | Halil Koyuncu İlknur Aktaş Ahmet Dinç İmdat Özkul Teoman Aydın Erdal Yücel Ömer Kocaman Halime Toros |
| author_facet | Halil Koyuncu İlknur Aktaş Ahmet Dinç İmdat Özkul Teoman Aydın Erdal Yücel Ömer Kocaman Halime Toros |
| author_sort | Halil Koyuncu |
| collection | DOAJ |
| description | The aim of this study was to determine whether depression was affect on bone loss in postmenopausal osteoporotic (PMO) women and response to calcitriol treatment in this patients. Seventy two females (mean age 65 ± 6.9) were included in this study. Out of these patients, 27 (37.5%) had depression, 45 (62.5%) were normal. All cases were evaluated by DXA, Hamilton depression scale, Short Form-36 (SF-36) scale and visual analog scale.
In the patients with depression, L1-L4 t-score (-3.29 ± 1.07), femur total t-score (-2.60 ± 1.00) and z-score (-0.97 ± 0.82) were significantly lower than PMO patients without depression (respectively; -2.71 ± 0.83, -1.86 ± 1.16 and –0.50 ± 0.91). Improvement of t- and z- scores in both groups were statistically significant after calcitriol treatment. Improvement of L1-L4 t- and z-scores and femur neck t-score were higher in patients with depression. SF-36 scores (75.9 ± 19.8) were lower in patients with depression than patients without depression (86.5 ± 14.4) (p=0.041). Negative correlations between Hamilton score and L1-L4 z-score (R=-0.432, p=0.024), femur neck t-score (R=-0.528, p=0.005) were found before treatment. Improvement of pain in both groups were similar.
In conclusion, postmenopausal bone loss was higher and the response to calcitriol treatment was better in patients with depression. |
| first_indexed | 2024-04-10T11:33:15Z |
| format | Article |
| id | doaj.art-841e1ff3a8694019b323ae71a3a9b06e |
| institution | Directory Open Access Journal |
| issn | 2147-2653 |
| language | English |
| last_indexed | 2024-04-10T11:33:15Z |
| publishDate | 2003-12-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Osteoporoz Dergisi |
| spelling | doaj.art-841e1ff3a8694019b323ae71a3a9b06e2023-02-15T16:17:58ZengGalenos YayineviTürk Osteoporoz Dergisi2147-26532003-12-0194129136The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without DepressionHalil Koyuncu0İlknur Aktaş1Ahmet Dinç2İmdat Özkul3Teoman Aydın4Erdal Yücel5Ömer Kocaman6Halime Toros7İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalıİstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalıİstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim DalıSerbest HekimSSK Bezmi Alem Vakıf Gureba HastanesiSerbest Hekimİzzet Baysal Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalıİstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim DalıThe aim of this study was to determine whether depression was affect on bone loss in postmenopausal osteoporotic (PMO) women and response to calcitriol treatment in this patients. Seventy two females (mean age 65 ± 6.9) were included in this study. Out of these patients, 27 (37.5%) had depression, 45 (62.5%) were normal. All cases were evaluated by DXA, Hamilton depression scale, Short Form-36 (SF-36) scale and visual analog scale. In the patients with depression, L1-L4 t-score (-3.29 ± 1.07), femur total t-score (-2.60 ± 1.00) and z-score (-0.97 ± 0.82) were significantly lower than PMO patients without depression (respectively; -2.71 ± 0.83, -1.86 ± 1.16 and –0.50 ± 0.91). Improvement of t- and z- scores in both groups were statistically significant after calcitriol treatment. Improvement of L1-L4 t- and z-scores and femur neck t-score were higher in patients with depression. SF-36 scores (75.9 ± 19.8) were lower in patients with depression than patients without depression (86.5 ± 14.4) (p=0.041). Negative correlations between Hamilton score and L1-L4 z-score (R=-0.432, p=0.024), femur neck t-score (R=-0.528, p=0.005) were found before treatment. Improvement of pain in both groups were similar. In conclusion, postmenopausal bone loss was higher and the response to calcitriol treatment was better in patients with depression.http://www.turkosteoporozdergisi.org/article_4190/The-Evaluation-Of-Efficacy-Of-Calcitriol-On-Bone-Mineral-Density-Pain-And-Quality-Of-Life-In-Postmenopausal-Osteoporotic-Patients-With-Or-Without-DepressionCalcitriol; Depression; Postmenopausal osteoporosis |
| spellingShingle | Halil Koyuncu İlknur Aktaş Ahmet Dinç İmdat Özkul Teoman Aydın Erdal Yücel Ömer Kocaman Halime Toros The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression Türk Osteoporoz Dergisi Calcitriol; Depression; Postmenopausal osteoporosis |
| title | The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression |
| title_full | The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression |
| title_fullStr | The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression |
| title_full_unstemmed | The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression |
| title_short | The Evaluation of Efficacy of Calcitriol on Bone Mineral Density, Pain and Quality of Life in Postmenopausal Osteoporotic Patients With or Without Depression |
| title_sort | evaluation of efficacy of calcitriol on bone mineral density pain and quality of life in postmenopausal osteoporotic patients with or without depression |
| topic | Calcitriol; Depression; Postmenopausal osteoporosis |
| url | http://www.turkosteoporozdergisi.org/article_4190/The-Evaluation-Of-Efficacy-Of-Calcitriol-On-Bone-Mineral-Density-Pain-And-Quality-Of-Life-In-Postmenopausal-Osteoporotic-Patients-With-Or-Without-Depression |
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