Characterization of Three Somatic Mutations in the 3′UTR of <i>RRAS2</i> and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia

Characterization of Three Somatic Mutations in the 3′UTR of <i>RRAS2</i> and Their Inverse Correlation with Lymphocytosis in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is a hematologic malignancy characterized by progressive accumulation of a rare population of CD5+ B-lymphocytes in peripheral blood, bone marrow, and lymphoid tissues. CLL exhibits remarkable clinical heterogeneity, with some patients presenting with indolent dise...

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Bibliographic Details
Main Authors: Marta Lacuna, Alejandro M. Hortal, Claudia Cifuentes, Tania Gonzalo, Miguel Alcoceba, Miguel Bastos, Xosé R. Bustelo, Marcos González, Balbino Alarcón
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
<i>RRAS2</i>
somatic mutations
3′ untranslated region
Chronic Lymphocytic Leukemia (CLL)
clinical implications
Online Access:https://www.mdpi.com/2073-4409/12/23/2687

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