Neurotization of the human cornea – A comprehensive review and an interim report
We present a comprehensive review of existing literature on surgical corneal neurotization (SCN) as a treatment modality for neurotrophic keratopathy (NK) with an interim report of seven cases where SCN was performed using the indirect approach and followed up till 18 months postoperatively to look...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=6;spage=1905;epage=1917;aulast=Rathi |
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| author | Anubha Rathi Nandini Bothra Smruti R Priyadarshini Divya S R Achanta Merle Fernandes Somasheila I Murthy Anasua G Kapoor Tarjani V Dave Suryasnata Rath Rajesh Yellinedi Rambabu Nuvvula Gautam Dendukuri Milind N Naik Muralidhar Ramappa |
| author_facet | Anubha Rathi Nandini Bothra Smruti R Priyadarshini Divya S R Achanta Merle Fernandes Somasheila I Murthy Anasua G Kapoor Tarjani V Dave Suryasnata Rath Rajesh Yellinedi Rambabu Nuvvula Gautam Dendukuri Milind N Naik Muralidhar Ramappa |
| author_sort | Anubha Rathi |
| collection | DOAJ |
| description | We present a comprehensive review of existing literature on surgical corneal neurotization (SCN) as a treatment modality for neurotrophic keratopathy (NK) with an interim report of seven cases where SCN was performed using the indirect approach and followed up till 18 months postoperatively to look for improvement in ocular surface, corneal sensations, and nerve regeneration by using in vivo confocal microscopy (IVCM). A literature search was performed for publications with keywords “corneal nerves,” “neurotization,” “esthesiometry,” “corneal anesthesia,” and “neurotrophic keratopathy.” All literature available till December 31, 2020 was reviewed and included to describe NK and its management options, particularly SCN. NK is associated with absent or reduced corneal sensations and is managed using a step-ladder algorithm ranging from medical management for symptomatic relief to surgical corneal neurotization. Both direct and indirect approaches of SCN have a favorable outcome with reduced surgical morbidity in the indirect approach using sural nerve graft. Post neurotization, corneal sensation recovery may take up to 3–6 months, while nerve regeneration on confocal microscopy can take as long as 6 months–1 year. |
| first_indexed | 2024-12-12T11:42:43Z |
| format | Article |
| id | doaj.art-841f85e3035b44d68b37a313201b8870 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-12T11:42:43Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-841f85e3035b44d68b37a313201b88702022-12-22T00:25:30ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892022-01-017061905191710.4103/ijo.IJO_2030_21Neurotization of the human cornea – A comprehensive review and an interim reportAnubha RathiNandini BothraSmruti R PriyadarshiniDivya S R AchantaMerle FernandesSomasheila I MurthyAnasua G KapoorTarjani V DaveSuryasnata RathRajesh YellinediRambabu NuvvulaGautam DendukuriMilind N NaikMuralidhar RamappaWe present a comprehensive review of existing literature on surgical corneal neurotization (SCN) as a treatment modality for neurotrophic keratopathy (NK) with an interim report of seven cases where SCN was performed using the indirect approach and followed up till 18 months postoperatively to look for improvement in ocular surface, corneal sensations, and nerve regeneration by using in vivo confocal microscopy (IVCM). A literature search was performed for publications with keywords “corneal nerves,” “neurotization,” “esthesiometry,” “corneal anesthesia,” and “neurotrophic keratopathy.” All literature available till December 31, 2020 was reviewed and included to describe NK and its management options, particularly SCN. NK is associated with absent or reduced corneal sensations and is managed using a step-ladder algorithm ranging from medical management for symptomatic relief to surgical corneal neurotization. Both direct and indirect approaches of SCN have a favorable outcome with reduced surgical morbidity in the indirect approach using sural nerve graft. Post neurotization, corneal sensation recovery may take up to 3–6 months, while nerve regeneration on confocal microscopy can take as long as 6 months–1 year.http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=6;spage=1905;epage=1917;aulast=Rathicorneal anesthesiacorneal nervesesthesiometryneurotizationneurotrophic keratopathy |
| spellingShingle | Anubha Rathi Nandini Bothra Smruti R Priyadarshini Divya S R Achanta Merle Fernandes Somasheila I Murthy Anasua G Kapoor Tarjani V Dave Suryasnata Rath Rajesh Yellinedi Rambabu Nuvvula Gautam Dendukuri Milind N Naik Muralidhar Ramappa Neurotization of the human cornea – A comprehensive review and an interim report Indian Journal of Ophthalmology corneal anesthesia corneal nerves esthesiometry neurotization neurotrophic keratopathy |
| title | Neurotization of the human cornea – A comprehensive review and an interim report |
| title_full | Neurotization of the human cornea – A comprehensive review and an interim report |
| title_fullStr | Neurotization of the human cornea – A comprehensive review and an interim report |
| title_full_unstemmed | Neurotization of the human cornea – A comprehensive review and an interim report |
| title_short | Neurotization of the human cornea – A comprehensive review and an interim report |
| title_sort | neurotization of the human cornea a comprehensive review and an interim report |
| topic | corneal anesthesia corneal nerves esthesiometry neurotization neurotrophic keratopathy |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2022;volume=70;issue=6;spage=1905;epage=1917;aulast=Rathi |
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