Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients
OBJECTIVES: Positive fluid balance is frequent in critically ill patients and has been considered a potential biomarker for acute kidney injury (AKI). This study aimed to evaluate positive fluid balance as a biomarker for the early detection of AKI in critically ill patients. METHODS: This was a pr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2021-02-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100224&tlng=en |
| _version_ | 1828197281167310848 |
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| author | Maria Olinda Nogueira Ávila Paulo Novis Rocha Caio A. Perez Tássia Nery Faustino Paulo Benigno Pena Batista Luis Yu Dirce Maria T. Zanetta Emmanuel A. Burdmann |
| author_facet | Maria Olinda Nogueira Ávila Paulo Novis Rocha Caio A. Perez Tássia Nery Faustino Paulo Benigno Pena Batista Luis Yu Dirce Maria T. Zanetta Emmanuel A. Burdmann |
| author_sort | Maria Olinda Nogueira Ávila |
| collection | DOAJ |
| description | OBJECTIVES: Positive fluid balance is frequent in critically ill patients and has been considered a potential biomarker for acute kidney injury (AKI). This study aimed to evaluate positive fluid balance as a biomarker for the early detection of AKI in critically ill patients. METHODS: This was a prospective cohort study. The sample was composed of patients ≥18 years old who stayed ≥3 days in an intensive care unit. Fluid balance, urinary output and serum creatinine were assessed daily. AKI was diagnosed by the Kidney Disease Improving Global Outcome criteria. RESULTS: The final cohort was composed of 233 patients. AKI occurred in 92 patients (40%) after a median of 3 (2-6) days following ICU admission. When fluid balance was assessed as a continuous variable, a 100-ml increase in fluid balance was independently associated with a 4% increase in the odds of AKI (OR 1.04; 95% CI 1.01-1.08). Positive fluid balance categorized using different thresholds was always significantly associated with subsequent detection of AKI. The mixed effects model showed that increased fluid balance preceded AKI by 4 to 6 days. CONCLUSION: These results suggest that a positive fluid balance might be an early biomarker for AKI development in critically ill patients. |
| first_indexed | 2024-04-12T10:16:59Z |
| format | Article |
| id | doaj.art-841f9df34ef848bb91be9411808f451c |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:16:59Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-841f9df34ef848bb91be9411808f451c2022-12-22T03:37:11ZengElsevier EspañaClinics1980-53222021-02-017610.6061/clinics/2021/e1924Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patientsMaria Olinda Nogueira Ávilahttps://orcid.org/0000-0001-7818-7344Paulo Novis Rochahttps://orcid.org/0000-0001-9598-6711Caio A. Perezhttps://orcid.org/0000-0002-1961-8439Tássia Nery Faustinohttps://orcid.org/0000-0001-7854-4540Paulo Benigno Pena Batistahttps://orcid.org/0000-0003-3394-1774Luis Yuhttps://orcid.org/0000-0001-9102-0063Dirce Maria T. Zanettahttps://orcid.org/0000-0002-7273-5087Emmanuel A. Burdmannhttps://orcid.org/0000-0002-7644-8579OBJECTIVES: Positive fluid balance is frequent in critically ill patients and has been considered a potential biomarker for acute kidney injury (AKI). This study aimed to evaluate positive fluid balance as a biomarker for the early detection of AKI in critically ill patients. METHODS: This was a prospective cohort study. The sample was composed of patients ≥18 years old who stayed ≥3 days in an intensive care unit. Fluid balance, urinary output and serum creatinine were assessed daily. AKI was diagnosed by the Kidney Disease Improving Global Outcome criteria. RESULTS: The final cohort was composed of 233 patients. AKI occurred in 92 patients (40%) after a median of 3 (2-6) days following ICU admission. When fluid balance was assessed as a continuous variable, a 100-ml increase in fluid balance was independently associated with a 4% increase in the odds of AKI (OR 1.04; 95% CI 1.01-1.08). Positive fluid balance categorized using different thresholds was always significantly associated with subsequent detection of AKI. The mixed effects model showed that increased fluid balance preceded AKI by 4 to 6 days. CONCLUSION: These results suggest that a positive fluid balance might be an early biomarker for AKI development in critically ill patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100224&tlng=enAcute Kidney InjuryBiomarkerPositive Fluid BalanceWater BalanceIntensive Care UnitMortality |
| spellingShingle | Maria Olinda Nogueira Ávila Paulo Novis Rocha Caio A. Perez Tássia Nery Faustino Paulo Benigno Pena Batista Luis Yu Dirce Maria T. Zanetta Emmanuel A. Burdmann Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients Clinics Acute Kidney Injury Biomarker Positive Fluid Balance Water Balance Intensive Care Unit Mortality |
| title | Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients |
| title_full | Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients |
| title_fullStr | Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients |
| title_full_unstemmed | Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients |
| title_short | Positive fluid balance as an early biomarker for acute kidney injury: a prospective study in critically ill adult patients |
| title_sort | positive fluid balance as an early biomarker for acute kidney injury a prospective study in critically ill adult patients |
| topic | Acute Kidney Injury Biomarker Positive Fluid Balance Water Balance Intensive Care Unit Mortality |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100224&tlng=en |
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