α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.

α-Actinin-2 mediates spine morphology and assembly of the post-synaptic density in hippocampal neurons.

Dendritic spines are micron-sized protrusions that constitute the primary post-synaptic sites of excitatory neurotransmission in the brain. Spines mature from a filopodia-like protrusion into a mushroom-shaped morphology with a post-synaptic density (PSD) at its tip. Modulation of the actin cytoskel...

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Bibliographic Details
Main Authors: Jennifer L Hodges, Samuel Martin Vilchez, Hannelore Asmussen, Leanna A Whitmore, Alan Rick Horwitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4090192?pdf=render

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