An integrated tool to study MHC region: accurate SNV detection and HLA genes typing in human MHC region using targeted high-throughput sequencing.

An integrated tool to study MHC region: accurate SNV detection and HLA genes typing in human MHC region using targeted high-throughput sequencing.

The major histocompatibility complex (MHC) is one of the most variable and gene-dense regions of the human genome. Most studies of the MHC, and associated regions, focus on minor variants and HLA typing, many of which have been demonstrated to be associated with human disease susceptibility and meta...

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Bibliographic Details
Main Authors: Hongzhi Cao, Jinghua Wu, Yu Wang, Hui Jiang, Tao Zhang, Xiao Liu, Yinyin Xu, Dequan Liang, Peng Gao, Yepeng Sun, Benjamin Gifford, Mark D'Ascenzo, Xiaomin Liu, Laurent C A M Tellier, Fang Yang, Xin Tong, Dan Chen, Jing Zheng, Weiyang Li, Todd Richmond, Xun Xu, Jun Wang, Yingrui Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3722289?pdf=render

Internet

http://europepmc.org/articles/PMC3722289?pdf=render

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