Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling

Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling

Abstract Background Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common cause of chronic liver disease in children and adolescents, but its etiology remains largely unknown. Adrenarche is a critical phase for hormonal changes, and any disturbance during this period has been...

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Bibliographic Details
Main Authors: Haoqing Li, Yingyu Liu, Fengyan Meng, Junan Chen, Xingfa Han
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Genomics
Subjects:
NAFLD
Adrenarche
De novo lipogenesis
Srebf1
Rat
Online Access:https://doi.org/10.1186/s12864-024-10107-6

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