Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
The adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.666881/full |
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| author | Sara Rojas-Vázquez Sara Rojas-Vázquez Sara Rojas-Vázquez Laura Blasco-Chamarro Laura Blasco-Chamarro Laura Blasco-Chamarro Irene López-Fabuel Irene López-Fabuel Irene López-Fabuel Ramón Martínez-Máñez Ramón Martínez-Máñez Ramón Martínez-Máñez Ramón Martínez-Máñez Isabel Fariñas Isabel Fariñas Isabel Fariñas |
| author_facet | Sara Rojas-Vázquez Sara Rojas-Vázquez Sara Rojas-Vázquez Laura Blasco-Chamarro Laura Blasco-Chamarro Laura Blasco-Chamarro Irene López-Fabuel Irene López-Fabuel Irene López-Fabuel Ramón Martínez-Máñez Ramón Martínez-Máñez Ramón Martínez-Máñez Ramón Martínez-Máñez Isabel Fariñas Isabel Fariñas Isabel Fariñas |
| author_sort | Sara Rojas-Vázquez |
| collection | DOAJ |
| description | The adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of these specialized niches provides multiple cellular and molecular signals that condition NSC behavior and potential. Among the different niche components, vasculature has gained increasing interest over the years due to its undeniable role in NSC regulation and its therapeutic potential for neurogenesis enhancement. NSCs are uniquely positioned to receive both locally secreted factors and adhesion-mediated signals derived from vascular elements. Furthermore, studies of parabiosis indicate that NSCs are also exposed to blood-borne factors, sensing and responding to the systemic circulation. Both structural and functional alterations occur in vasculature with age at the cellular level that can affect the proper extrinsic regulation of NSCs. Additionally, blood exchange experiments in heterochronic parabionts have revealed that age-associated changes in blood composition also contribute to adult neurogenesis impairment in the elderly. Although the mechanisms of vascular- or blood-derived signaling in aging are still not fully understood, a general feature of organismal aging is the accumulation of senescent cells, which act as sources of inflammatory and other detrimental signals that can negatively impact on neighboring cells. This review focuses on the interactions between vascular senescence, circulating pro-senescence factors and the decrease in NSC potential during aging. Understanding the mechanisms of NSC dynamics in the aging brain could lead to new therapeutic approaches, potentially include senolysis, to target age-dependent brain decline. |
| first_indexed | 2024-12-20T12:34:47Z |
| format | Article |
| id | doaj.art-84273cec0cd1406cabd7089aef5f9ef4 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T12:34:47Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-84273cec0cd1406cabd7089aef5f9ef42022-12-21T19:40:37ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-04-011510.3389/fnins.2021.666881666881Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic DeclineSara Rojas-Vázquez0Sara Rojas-Vázquez1Sara Rojas-Vázquez2Laura Blasco-Chamarro3Laura Blasco-Chamarro4Laura Blasco-Chamarro5Irene López-Fabuel6Irene López-Fabuel7Irene López-Fabuel8Ramón Martínez-Máñez9Ramón Martínez-Máñez10Ramón Martínez-Máñez11Ramón Martínez-Máñez12Isabel Fariñas13Isabel Fariñas14Isabel Fariñas15Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Valencia, SpainCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Valencia, SpainDepartamento de Biología Celular, Biología Funcional y Antropología Física, Universitat de València, Valencia, SpainDepartamento de Biología Celular, Biología Funcional y Antropología Física, Universitat de València, Valencia, SpainInstituto de Biotecnología y Biomedicina (BioTecMed), Universitat de València, Valencia, SpainCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, SpainDepartamento de Biología Celular, Biología Funcional y Antropología Física, Universitat de València, Valencia, SpainInstituto de Biotecnología y Biomedicina (BioTecMed), Universitat de València, Valencia, SpainCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, SpainInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Valencia, SpainCentro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Valencia, SpainUnidad Mixta UPV-CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Valencia, SpainUnidad Mixta de Investigación en Nanomedicina y Sensores, Universitat Politècnica de València, IIS La Fe, Valencia, SpainDepartamento de Biología Celular, Biología Funcional y Antropología Física, Universitat de València, Valencia, SpainInstituto de Biotecnología y Biomedicina (BioTecMed), Universitat de València, Valencia, SpainCentro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, SpainThe adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of these specialized niches provides multiple cellular and molecular signals that condition NSC behavior and potential. Among the different niche components, vasculature has gained increasing interest over the years due to its undeniable role in NSC regulation and its therapeutic potential for neurogenesis enhancement. NSCs are uniquely positioned to receive both locally secreted factors and adhesion-mediated signals derived from vascular elements. Furthermore, studies of parabiosis indicate that NSCs are also exposed to blood-borne factors, sensing and responding to the systemic circulation. Both structural and functional alterations occur in vasculature with age at the cellular level that can affect the proper extrinsic regulation of NSCs. Additionally, blood exchange experiments in heterochronic parabionts have revealed that age-associated changes in blood composition also contribute to adult neurogenesis impairment in the elderly. Although the mechanisms of vascular- or blood-derived signaling in aging are still not fully understood, a general feature of organismal aging is the accumulation of senescent cells, which act as sources of inflammatory and other detrimental signals that can negatively impact on neighboring cells. This review focuses on the interactions between vascular senescence, circulating pro-senescence factors and the decrease in NSC potential during aging. Understanding the mechanisms of NSC dynamics in the aging brain could lead to new therapeutic approaches, potentially include senolysis, to target age-dependent brain decline.https://www.frontiersin.org/articles/10.3389/fnins.2021.666881/fulladult neural stem cellneurogenic nicheendothelial cell senescencesenescence-associated secretory phenotypeparabiosis |
| spellingShingle | Sara Rojas-Vázquez Sara Rojas-Vázquez Sara Rojas-Vázquez Laura Blasco-Chamarro Laura Blasco-Chamarro Laura Blasco-Chamarro Irene López-Fabuel Irene López-Fabuel Irene López-Fabuel Ramón Martínez-Máñez Ramón Martínez-Máñez Ramón Martínez-Máñez Ramón Martínez-Máñez Isabel Fariñas Isabel Fariñas Isabel Fariñas Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline Frontiers in Neuroscience adult neural stem cell neurogenic niche endothelial cell senescence senescence-associated secretory phenotype parabiosis |
| title | Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline |
| title_full | Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline |
| title_fullStr | Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline |
| title_full_unstemmed | Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline |
| title_short | Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline |
| title_sort | vascular senescence a potential bridge between physiological aging and neurogenic decline |
| topic | adult neural stem cell neurogenic niche endothelial cell senescence senescence-associated secretory phenotype parabiosis |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.666881/full |
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