Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine

BackgroundMicroemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was c...

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Main Authors: Yong Ku Han, Cheol Won Jeong, Hyung Gon Lee
Format: Article
Language:English
Published: Korean Society of Anesthesiologists 2010-05-01
Series:Korean Journal of Anesthesiology
Subjects:
Online Access:http://ekja.org/upload/pdf/kjae-58-435.pdf
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author Yong Ku Han
Cheol Won Jeong
Hyung Gon Lee
author_facet Yong Ku Han
Cheol Won Jeong
Hyung Gon Lee
author_sort Yong Ku Han
collection DOAJ
description BackgroundMicroemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was compared with microemulsion propofol accompanied with either remifentanil or lidocaine.MethodsOne hundred twenty patients aged between 20-65 years old were allocated randomly into one of three groups (n = 40, in each). The patients in the remifentanil group received remifentanil 0.5 µg/kg IV for 30 seconds before a microemulsion propofol injection. The patients in the lidocaine group received propofol 2 mg/kg premixed with 40 mg lidocaine over a 60 second period. The patients in the combination group received both remifentanil and lidocaine.ResultsThere was a significantly lower incidence of microemulsion propofol injection pain (severity 2 or more) in the combination group (12.5%) than in the remifentanil and lidocaine groups (90% and 65%, respectively, P < 0.05). The incidence of moderate pain disappeared completely in the combination group (0%) compared to that in the remifentanil and lidocaine group (32.5% and 20%, respectively, P < 0.05). Severe pain did not appear in any of the three groups. There were no complications on the injection site in the lidocaine alone and combination groups.ConclusionsThe combination of microemulsion propofol premixed with lidocaine after a pretreatment with remifentanil was more effective in reducing the incidence of pain upon the injection of microemulsion propofol than either treatment alone.
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spelling doaj.art-842b670feb1a4ca59b2b021060f4d9242022-12-21T17:49:26ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632010-05-0158543543910.4097/kjae.2010.58.5.4356896Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaineYong Ku Han0Cheol Won Jeong1Hyung Gon Lee2Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, Korea.BackgroundMicroemulsion propofol produces more frequent and severe pain upon injection than lipid emulsion propofol. This study examined the analgesic effect of lidocaine-premixed microemulsion propofol in patients pretreated with remifentanil. The induction of anesthesia with this combination was compared with microemulsion propofol accompanied with either remifentanil or lidocaine.MethodsOne hundred twenty patients aged between 20-65 years old were allocated randomly into one of three groups (n = 40, in each). The patients in the remifentanil group received remifentanil 0.5 µg/kg IV for 30 seconds before a microemulsion propofol injection. The patients in the lidocaine group received propofol 2 mg/kg premixed with 40 mg lidocaine over a 60 second period. The patients in the combination group received both remifentanil and lidocaine.ResultsThere was a significantly lower incidence of microemulsion propofol injection pain (severity 2 or more) in the combination group (12.5%) than in the remifentanil and lidocaine groups (90% and 65%, respectively, P < 0.05). The incidence of moderate pain disappeared completely in the combination group (0%) compared to that in the remifentanil and lidocaine group (32.5% and 20%, respectively, P < 0.05). Severe pain did not appear in any of the three groups. There were no complications on the injection site in the lidocaine alone and combination groups.ConclusionsThe combination of microemulsion propofol premixed with lidocaine after a pretreatment with remifentanil was more effective in reducing the incidence of pain upon the injection of microemulsion propofol than either treatment alone.http://ekja.org/upload/pdf/kjae-58-435.pdfintravenous anestheticslidocainemicroemulsion propofolpainremifentanil
spellingShingle Yong Ku Han
Cheol Won Jeong
Hyung Gon Lee
Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine
Korean Journal of Anesthesiology
intravenous anesthetics
lidocaine
microemulsion propofol
pain
remifentanil
title Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine
title_full Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine
title_fullStr Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine
title_full_unstemmed Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine
title_short Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine
title_sort pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine
topic intravenous anesthetics
lidocaine
microemulsion propofol
pain
remifentanil
url http://ekja.org/upload/pdf/kjae-58-435.pdf
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AT hyunggonlee painreductiononinjectionofmicroemulsionpropofolviacombinationofremifentanilandlidocaine