Serine protease inhibitors and human wellbeing interplay: new insights for old friends
Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets. Several studies provided functional and structural data about human serpins...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2019-08-01
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| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/7224.pdf |
| _version_ | 1797423782473760768 |
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| author | Héla Mkaouar Nizar Akermi Aicha Kriaa Anne-Laure Abraham Amin Jablaoui Souha Soussou Raja Mokdad-Gargouri Emmanuelle Maguin Moez Rhimi |
| author_facet | Héla Mkaouar Nizar Akermi Aicha Kriaa Anne-Laure Abraham Amin Jablaoui Souha Soussou Raja Mokdad-Gargouri Emmanuelle Maguin Moez Rhimi |
| author_sort | Héla Mkaouar |
| collection | DOAJ |
| description | Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets. Several studies provided functional and structural data about human serpins. By comparison, only little knowledge regarding bacterial serpins exists. Through the emergence of metagenomic studies, many bacterial serpins were identified from numerous ecological niches including the human gut microbiota. The origin, distribution and function of these proteins remain to be established. In this report, we shed light on the key role of human and bacterial serpins in health and disease. Moreover, we analyze their function, phylogeny and ecological distribution. This review highlights the potential use of bacterial serpins to set out new therapeutic approaches. |
| first_indexed | 2024-03-09T07:52:46Z |
| format | Article |
| id | doaj.art-842c165203e44ed6b8277951faeeb013 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:52:46Z |
| publishDate | 2019-08-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-842c165203e44ed6b8277951faeeb0132023-12-03T01:26:40ZengPeerJ Inc.PeerJ2167-83592019-08-017e722410.7717/peerj.7224Serine protease inhibitors and human wellbeing interplay: new insights for old friendsHéla Mkaouar0Nizar Akermi1Aicha Kriaa2Anne-Laure Abraham3Amin Jablaoui4Souha Soussou5Raja Mokdad-Gargouri6Emmanuelle Maguin7Moez Rhimi8INRA, UMR1319 MICALIS, Jouy-en-Josas, France, AgroParisTech, UMR MICALIS, Jouy-en-Josas, FranceINRA, UMR1319 MICALIS, Jouy-en-Josas, France, AgroParisTech, UMR MICALIS, Jouy-en-Josas, FranceINRA, UMR1319 MICALIS, Jouy-en-Josas, France, AgroParisTech, UMR MICALIS, Jouy-en-Josas, FranceMaIAGE, INRA, Université Paris-Saclay, Jouy-en-Josas, FranceINRA, UMR1319 MICALIS, Jouy-en-Josas, France, AgroParisTech, UMR MICALIS, Jouy-en-Josas, FranceINRA, UMR1319 MICALIS, Jouy-en-Josas, France, AgroParisTech, UMR MICALIS, Jouy-en-Josas, FranceLaboratory of Molecular Biology of Eukaryotes, Center of Biotechnology of Sfax, University of Sfax, Sfax, TunisiaINRA, UMR1319 MICALIS, Jouy-en-Josas, France, AgroParisTech, UMR MICALIS, Jouy-en-Josas, FranceINRA, UMR1319 MICALIS, Jouy-en-Josas, France, AgroParisTech, UMR MICALIS, Jouy-en-Josas, FranceSerine Protease Inhibitors (Serpins) control tightly regulated physiological processes and their dysfunction is associated to various diseases. Thus, increasing interest is given to these proteins as new therapeutic targets. Several studies provided functional and structural data about human serpins. By comparison, only little knowledge regarding bacterial serpins exists. Through the emergence of metagenomic studies, many bacterial serpins were identified from numerous ecological niches including the human gut microbiota. The origin, distribution and function of these proteins remain to be established. In this report, we shed light on the key role of human and bacterial serpins in health and disease. Moreover, we analyze their function, phylogeny and ecological distribution. This review highlights the potential use of bacterial serpins to set out new therapeutic approaches.https://peerj.com/articles/7224.pdfSerine protease inhibitorsDiseaseHomeostasisFunctionHuman gut microbiota |
| spellingShingle | Héla Mkaouar Nizar Akermi Aicha Kriaa Anne-Laure Abraham Amin Jablaoui Souha Soussou Raja Mokdad-Gargouri Emmanuelle Maguin Moez Rhimi Serine protease inhibitors and human wellbeing interplay: new insights for old friends PeerJ Serine protease inhibitors Disease Homeostasis Function Human gut microbiota |
| title | Serine protease inhibitors and human wellbeing interplay: new insights for old friends |
| title_full | Serine protease inhibitors and human wellbeing interplay: new insights for old friends |
| title_fullStr | Serine protease inhibitors and human wellbeing interplay: new insights for old friends |
| title_full_unstemmed | Serine protease inhibitors and human wellbeing interplay: new insights for old friends |
| title_short | Serine protease inhibitors and human wellbeing interplay: new insights for old friends |
| title_sort | serine protease inhibitors and human wellbeing interplay new insights for old friends |
| topic | Serine protease inhibitors Disease Homeostasis Function Human gut microbiota |
| url | https://peerj.com/articles/7224.pdf |
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