ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.
Diffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24819368/?tool=EBI |
| _version_ | 1819100747723177984 |
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| author | Bence Gunda Raphael Porcher Marco Duering Jean-Pierre Guichard Jerome Mawet Eric Jouvent Martin Dichgans Hugues Chabriat |
| author_facet | Bence Gunda Raphael Porcher Marco Duering Jean-Pierre Guichard Jerome Mawet Eric Jouvent Martin Dichgans Hugues Chabriat |
| author_sort | Bence Gunda |
| collection | DOAJ |
| description | Diffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL patients were evaluated by DWI and DTI in a large cohort study over a 6-year period. ADC histogram parameters were compared to those derived from mean diffusivity (MD) histograms in 280 patients using intra-class correlation and Bland-Altman plots. Impact of image corrections applied to ADC maps was assessed and a mixed effect model was used for analyzing the effects of scanner upgrades. The results showed that ADC histogram parameters are strongly correlated to MD histogram parameters and that image corrections have only limited influence on these results. Unexpectedly, scanner upgrades were found to have major effects on diffusion measures with DWI or DTI that can be even larger than those related to patients' characteristics. These data support that ADC histograms from daily used DWI can provide relevant parameters for assessing cSVD, but the variability related to scanner upgrades as regularly performed in clinical centers should be determined precisely for longitudinal and multicentric studies using diffusion MRI in cSVD. |
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| id | doaj.art-842cabf1d09142019e1b55195ea4eea2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T01:07:42Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-842cabf1d09142019e1b55195ea4eea22022-12-21T18:44:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0195e9717310.1371/journal.pone.0097173ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL.Bence GundaRaphael PorcherMarco DueringJean-Pierre GuichardJerome MawetEric JouventMartin DichgansHugues ChabriatDiffusion tensor imaging (DTI) histogram metrics are correlated with clinical parameters in cerebral small vessel diseases (cSVD). Whether ADC histogram parameters derived from simple diffusion weighted imaging (DWI) can provide relevant markers for long term studies of cSVD remains unknown. CADASIL patients were evaluated by DWI and DTI in a large cohort study over a 6-year period. ADC histogram parameters were compared to those derived from mean diffusivity (MD) histograms in 280 patients using intra-class correlation and Bland-Altman plots. Impact of image corrections applied to ADC maps was assessed and a mixed effect model was used for analyzing the effects of scanner upgrades. The results showed that ADC histogram parameters are strongly correlated to MD histogram parameters and that image corrections have only limited influence on these results. Unexpectedly, scanner upgrades were found to have major effects on diffusion measures with DWI or DTI that can be even larger than those related to patients' characteristics. These data support that ADC histograms from daily used DWI can provide relevant parameters for assessing cSVD, but the variability related to scanner upgrades as regularly performed in clinical centers should be determined precisely for longitudinal and multicentric studies using diffusion MRI in cSVD.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24819368/?tool=EBI |
| spellingShingle | Bence Gunda Raphael Porcher Marco Duering Jean-Pierre Guichard Jerome Mawet Eric Jouvent Martin Dichgans Hugues Chabriat ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL. PLoS ONE |
| title | ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL. |
| title_full | ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL. |
| title_fullStr | ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL. |
| title_full_unstemmed | ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL. |
| title_short | ADC histograms from routine DWI for longitudinal studies in cerebral small vessel disease: a field study in CADASIL. |
| title_sort | adc histograms from routine dwi for longitudinal studies in cerebral small vessel disease a field study in cadasil |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24819368/?tool=EBI |
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