A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of Schizophrenia
Background: Schizophrenia is a severe and complex disease with substantial economic and social burdens. Despite multiple treatment choices, adverse events, and impaired social functions are still challenges in clinical therapy. Pharmacoeconomic evaluations could provide evidence to help decision mak...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2021.689123/full |
| _version_ | 1819109754713145344 |
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| author | Luying Wang Luying Wang Fenghao Shi Fenghao Shi Xin Guan Xin Guan He Xu He Xu Jing Liu Hongchao Li Hongchao Li |
| author_facet | Luying Wang Luying Wang Fenghao Shi Fenghao Shi Xin Guan Xin Guan He Xu He Xu Jing Liu Hongchao Li Hongchao Li |
| author_sort | Luying Wang |
| collection | DOAJ |
| description | Background: Schizophrenia is a severe and complex disease with substantial economic and social burdens. Despite multiple treatment choices, adverse events, and impaired social functions are still challenges in clinical therapy. Pharmacoeconomic evaluations could provide evidence to help decision makers improve the utilization of scarce resources. However, there remains some challenges especially in modeling due to uncertainties in progression of schizophrenia. There are limited summaries about the overall methodologies of schizophrenia economic evaluations.Objective: The aim of this study is to review the existing economic evaluations of antipsychotics for the treatment of schizophrenia and summarize the evidence and methods applied.Methods: An electronic literature search was performed in PubMed, Web of Science, EBSCO host, The Cochrane Library and ScienceDirect from January 2014 to December 2020. Search terms included “schizophrenia,” “schizophrenic,” “pharmacoeconomic,” “economic evaluation,” “cost-effectiveness,” and “cost-utility.” The Literature was screened and extracted by two researchers independently and assessed with the Quality of Health Economic Studies (QHES) List and Consolidated Health Economic Evaluation Reporting Standards (CHEERS) Statement.Results: A total of 25 studies were included in the review. The regions included Europe, North America, Asia and Africa. Most of the studies chose second-generation antipsychotics as comparators and integrated treatment sequences. Time horizons varied from 1 year to lifetime. The healthcare sector was the most common perspective, accordingly, most of the evaluations considered only direct medical costs. The Markov model and decision tree model were the most common choices. Adverse events, compliance and persistence were considered important parameters. Quality-adjusted life-years were the major outcomes applied to the economic evaluations. All utilities for health states and adverse events were collected from published literature. All of the studies applied uncertainty analysis to explore the robustness of the results. The quality of the studies was generally satisfactory. However, improvements were needed in the choice of time horizons, the measurements of outcomes and the descriptions of assumptions.Conclusions: This study highlights the methodology of economic evaluation of schizophrenia. Recommendations for modeling method and future study are provided. |
| first_indexed | 2024-12-22T03:30:51Z |
| format | Article |
| id | doaj.art-842cf36c61aa40498d0439145706eb22 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-22T03:30:51Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-842cf36c61aa40498d0439145706eb222022-12-21T18:40:31ZengFrontiers Media S.A.Frontiers in Public Health2296-25652021-10-01910.3389/fpubh.2021.689123689123A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of SchizophreniaLuying Wang0Luying Wang1Fenghao Shi2Fenghao Shi3Xin Guan4Xin Guan5He Xu6He Xu7Jing Liu8Hongchao Li9Hongchao Li10School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, ChinaCenter for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, ChinaSchool of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, ChinaCenter for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, ChinaSchool of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, ChinaCenter for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, ChinaSchool of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, ChinaCenter for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, ChinaSumitomo Pharma (Suzhou) Co., Ltd., Shanghai, ChinaSchool of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, ChinaCenter for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, ChinaBackground: Schizophrenia is a severe and complex disease with substantial economic and social burdens. Despite multiple treatment choices, adverse events, and impaired social functions are still challenges in clinical therapy. Pharmacoeconomic evaluations could provide evidence to help decision makers improve the utilization of scarce resources. However, there remains some challenges especially in modeling due to uncertainties in progression of schizophrenia. There are limited summaries about the overall methodologies of schizophrenia economic evaluations.Objective: The aim of this study is to review the existing economic evaluations of antipsychotics for the treatment of schizophrenia and summarize the evidence and methods applied.Methods: An electronic literature search was performed in PubMed, Web of Science, EBSCO host, The Cochrane Library and ScienceDirect from January 2014 to December 2020. Search terms included “schizophrenia,” “schizophrenic,” “pharmacoeconomic,” “economic evaluation,” “cost-effectiveness,” and “cost-utility.” The Literature was screened and extracted by two researchers independently and assessed with the Quality of Health Economic Studies (QHES) List and Consolidated Health Economic Evaluation Reporting Standards (CHEERS) Statement.Results: A total of 25 studies were included in the review. The regions included Europe, North America, Asia and Africa. Most of the studies chose second-generation antipsychotics as comparators and integrated treatment sequences. Time horizons varied from 1 year to lifetime. The healthcare sector was the most common perspective, accordingly, most of the evaluations considered only direct medical costs. The Markov model and decision tree model were the most common choices. Adverse events, compliance and persistence were considered important parameters. Quality-adjusted life-years were the major outcomes applied to the economic evaluations. All utilities for health states and adverse events were collected from published literature. All of the studies applied uncertainty analysis to explore the robustness of the results. The quality of the studies was generally satisfactory. However, improvements were needed in the choice of time horizons, the measurements of outcomes and the descriptions of assumptions.Conclusions: This study highlights the methodology of economic evaluation of schizophrenia. Recommendations for modeling method and future study are provided.https://www.frontiersin.org/articles/10.3389/fpubh.2021.689123/fullschizophreniaeconomic evaluationsystematic reviewmodelingmethod review |
| spellingShingle | Luying Wang Luying Wang Fenghao Shi Fenghao Shi Xin Guan Xin Guan He Xu He Xu Jing Liu Hongchao Li Hongchao Li A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of Schizophrenia Frontiers in Public Health schizophrenia economic evaluation systematic review modeling method review |
| title | A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of Schizophrenia |
| title_full | A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of Schizophrenia |
| title_fullStr | A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of Schizophrenia |
| title_full_unstemmed | A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of Schizophrenia |
| title_short | A Systematic Review of Methods and Study Quality of Economic Evaluations for the Treatment of Schizophrenia |
| title_sort | systematic review of methods and study quality of economic evaluations for the treatment of schizophrenia |
| topic | schizophrenia economic evaluation systematic review modeling method review |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2021.689123/full |
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