Imaging perivascular space structure and function using brain MRI
In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste product...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-08-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922004487 |
| _version_ | 1811256163908452352 |
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| author | Giuseppe Barisano Kirsten M. Lynch Francesca Sibilia Haoyu Lan Nien-Chu Shih Farshid Sepehrband Jeiran Choupan |
| author_facet | Giuseppe Barisano Kirsten M. Lynch Francesca Sibilia Haoyu Lan Nien-Chu Shih Farshid Sepehrband Jeiran Choupan |
| author_sort | Giuseppe Barisano |
| collection | DOAJ |
| description | In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases. Novel strategies and techniques have been introduced to improve the quantification of PVS and to investigate their function and morphological features in physiological and pathological conditions. After a brief introduction on the anatomy and physiology of PVS, we examine the latest technological developments to quantitatively analyze the structure and function of PVS in humans with MRI. We describe the applications, advantages, and limitations of these methods, providing guidance and suggestions on the acquisition protocols and analysis techniques that can be applied to study PVS in vivo. Finally, we review the human neuroimaging studies on PVS across the normative lifespan and in the context of neurological disorders. |
| first_indexed | 2024-04-12T17:35:56Z |
| format | Article |
| id | doaj.art-8430119c78a64475907f2760b22c0ae9 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-12T17:35:56Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-8430119c78a64475907f2760b22c0ae92022-12-22T03:22:59ZengElsevierNeuroImage1095-95722022-08-01257119329Imaging perivascular space structure and function using brain MRIGiuseppe Barisano0Kirsten M. Lynch1Francesca Sibilia2Haoyu Lan3Nien-Chu Shih4Farshid Sepehrband5Jeiran Choupan6Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA; Corresponding author at: Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USA.Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USALaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USALaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USALaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USALaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USALaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, USAIn this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases. Novel strategies and techniques have been introduced to improve the quantification of PVS and to investigate their function and morphological features in physiological and pathological conditions. After a brief introduction on the anatomy and physiology of PVS, we examine the latest technological developments to quantitatively analyze the structure and function of PVS in humans with MRI. We describe the applications, advantages, and limitations of these methods, providing guidance and suggestions on the acquisition protocols and analysis techniques that can be applied to study PVS in vivo. Finally, we review the human neuroimaging studies on PVS across the normative lifespan and in the context of neurological disorders.http://www.sciencedirect.com/science/article/pii/S1053811922004487Perivascular spacesStructural MRIDiffusion MRIUltra-high field MRI |
| spellingShingle | Giuseppe Barisano Kirsten M. Lynch Francesca Sibilia Haoyu Lan Nien-Chu Shih Farshid Sepehrband Jeiran Choupan Imaging perivascular space structure and function using brain MRI NeuroImage Perivascular spaces Structural MRI Diffusion MRI Ultra-high field MRI |
| title | Imaging perivascular space structure and function using brain MRI |
| title_full | Imaging perivascular space structure and function using brain MRI |
| title_fullStr | Imaging perivascular space structure and function using brain MRI |
| title_full_unstemmed | Imaging perivascular space structure and function using brain MRI |
| title_short | Imaging perivascular space structure and function using brain MRI |
| title_sort | imaging perivascular space structure and function using brain mri |
| topic | Perivascular spaces Structural MRI Diffusion MRI Ultra-high field MRI |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922004487 |
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