Entosis Is Induced by Glucose Starvation
Entosis is a mechanism of cell death that involves neighbor cell ingestion. This process occurs in cancers and promotes a form of cell competition, where winner cells engulf and kill losers. Entosis is driven by a mechanical differential that allows softer cells to eliminate stiffer cells. While thi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717308513 |
| _version_ | 1811208929477132288 |
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| author | Jens C. Hamann Alexandra Surcel Ruoyao Chen Carolyn Teragawa John G. Albeck Douglas N. Robinson Michael Overholtzer |
| author_facet | Jens C. Hamann Alexandra Surcel Ruoyao Chen Carolyn Teragawa John G. Albeck Douglas N. Robinson Michael Overholtzer |
| author_sort | Jens C. Hamann |
| collection | DOAJ |
| description | Entosis is a mechanism of cell death that involves neighbor cell ingestion. This process occurs in cancers and promotes a form of cell competition, where winner cells engulf and kill losers. Entosis is driven by a mechanical differential that allows softer cells to eliminate stiffer cells. While this process can be induced by matrix detachment, whether other stressors can activate entosis is unknown. Here, we find that entosis is induced in adherent cells by glucose withdrawal. Glucose withdrawal leads to a bimodal distribution of cells based on their deformability, where stiffer cells appear in a manner requiring the energy-sensing AMP-activated protein kinase (AMPK). We show that loser cells with high levels of AMPK activity are eliminated by winners through entosis, which supports winner cell proliferation under nutrient-deprived conditions. Our findings demonstrate that entosis serves as a cellular response to metabolic stress that enables nutrient recovery through neighbor cell ingestion. |
| first_indexed | 2024-04-12T04:30:11Z |
| format | Article |
| id | doaj.art-84311da285524b578a2a84e2f2fd339a |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-12T04:30:11Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-84311da285524b578a2a84e2f2fd339a2022-12-22T03:47:57ZengElsevierCell Reports2211-12472017-07-0120120121010.1016/j.celrep.2017.06.037Entosis Is Induced by Glucose StarvationJens C. Hamann0Alexandra Surcel1Ruoyao Chen2Carolyn Teragawa3John G. Albeck4Douglas N. Robinson5Michael Overholtzer6Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USADepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USACell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USADepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USADepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USADepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USACell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USAEntosis is a mechanism of cell death that involves neighbor cell ingestion. This process occurs in cancers and promotes a form of cell competition, where winner cells engulf and kill losers. Entosis is driven by a mechanical differential that allows softer cells to eliminate stiffer cells. While this process can be induced by matrix detachment, whether other stressors can activate entosis is unknown. Here, we find that entosis is induced in adherent cells by glucose withdrawal. Glucose withdrawal leads to a bimodal distribution of cells based on their deformability, where stiffer cells appear in a manner requiring the energy-sensing AMP-activated protein kinase (AMPK). We show that loser cells with high levels of AMPK activity are eliminated by winners through entosis, which supports winner cell proliferation under nutrient-deprived conditions. Our findings demonstrate that entosis serves as a cellular response to metabolic stress that enables nutrient recovery through neighbor cell ingestion.http://www.sciencedirect.com/science/article/pii/S2211124717308513entosiscell-in-cellcell deathglucose starvationAMPKcannibalismtensionmyosin |
| spellingShingle | Jens C. Hamann Alexandra Surcel Ruoyao Chen Carolyn Teragawa John G. Albeck Douglas N. Robinson Michael Overholtzer Entosis Is Induced by Glucose Starvation Cell Reports entosis cell-in-cell cell death glucose starvation AMPK cannibalism tension myosin |
| title | Entosis Is Induced by Glucose Starvation |
| title_full | Entosis Is Induced by Glucose Starvation |
| title_fullStr | Entosis Is Induced by Glucose Starvation |
| title_full_unstemmed | Entosis Is Induced by Glucose Starvation |
| title_short | Entosis Is Induced by Glucose Starvation |
| title_sort | entosis is induced by glucose starvation |
| topic | entosis cell-in-cell cell death glucose starvation AMPK cannibalism tension myosin |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717308513 |
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