Khat-drug interactions: A systematic review
Context: Consumption of khat leaves has been disseminated worldwide with the migration of its users from Arabia and Africa. Despite numerous reports regarding the associations of khat chewing with serious health impacts, a significant number of people worldwide uses khat daily, especially in its ori...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
GarVal Editorial Ltda.
2021-05-01
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| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | https://jppres.com/jppres/pdf/vol9/jppres20.951_9.3.333.pdf |
| _version_ | 1818366962599723008 |
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| author | Nabil Ahmed Albaser Abdel-Wahab H. Mohamad Mohammed Amood AL-Kamarany |
| author_facet | Nabil Ahmed Albaser Abdel-Wahab H. Mohamad Mohammed Amood AL-Kamarany |
| author_sort | Nabil Ahmed Albaser |
| collection | DOAJ |
| description | Context: Consumption of khat leaves has been disseminated worldwide with the migration of its users from Arabia and Africa. Despite numerous reports regarding the associations of khat chewing with serious health impacts, a significant number of people worldwide uses khat daily, especially in its origin countries. The risk of co-administration of khat and drugs (prescription and over the-counter medications) is high among these individuals, leading to increase probability of adverse khat-drug interactions. The likelihood of khat-drug interactions could be higher than drug-drug interactions because drugs usually contain single chemical entities while almost all herbs (including khat) contain mixtures of pharmacologically active constituents.
Aims: To review the literatures on how khat interacts with some drugs and whether it is favorable or not.
Methods: The study was conducted as a systematic review. The electronic literature searches were made in Google search engine to access publications from databases like PubMed, Google Scholar, and Cochrane using the keywords ‘khat’, ‘Catha edulis’ in combination with the terms ‘drug interaction’, ‘adverse-effects’, ‘side effects’, ‘adverse drug reaction’, ‘safety’, and ‘toxicity’ to identify relevant articles.
Results: A total of 250 articles was identified, and these articles were checked in terms of title, abstract, and content according to inclusion and exclusion criteria. Finally, 18 articles were included in the study. The khat use significantly interact with most drugs and may cause unpredictable pharmacological sequences.
Conclusions: Healthcare providers suggest patients` khat abstinence during medication process. Future studies need to investigate the khat- clinical drugs interactions especially with chronic used drugs. |
| first_indexed | 2024-12-13T22:44:30Z |
| format | Article |
| id | doaj.art-8431e5355d9742b6bcb27c75ca9a79c7 |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-13T22:44:30Z |
| publishDate | 2021-05-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-8431e5355d9742b6bcb27c75ca9a79c72022-12-21T23:28:47ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502021-05-0193333343Khat-drug interactions: A systematic reviewNabil Ahmed Albaser0Abdel-Wahab H. Mohamad1Mohammed Amood AL-Kamarany2Pharmacology Department, Faculty of Medical Sciences, Pharmacy, AL Razi University, Sana’a, Yemen. Department of Therapeutics, Pharmacy College, National Ribat University, Khartoum, Sudan.Department of Therapeutics, Pharmacy College, National Ribat University, Khartoum, Sudan.Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Hodeidah University, Hodeidah, Yemen.Context: Consumption of khat leaves has been disseminated worldwide with the migration of its users from Arabia and Africa. Despite numerous reports regarding the associations of khat chewing with serious health impacts, a significant number of people worldwide uses khat daily, especially in its origin countries. The risk of co-administration of khat and drugs (prescription and over the-counter medications) is high among these individuals, leading to increase probability of adverse khat-drug interactions. The likelihood of khat-drug interactions could be higher than drug-drug interactions because drugs usually contain single chemical entities while almost all herbs (including khat) contain mixtures of pharmacologically active constituents. Aims: To review the literatures on how khat interacts with some drugs and whether it is favorable or not. Methods: The study was conducted as a systematic review. The electronic literature searches were made in Google search engine to access publications from databases like PubMed, Google Scholar, and Cochrane using the keywords ‘khat’, ‘Catha edulis’ in combination with the terms ‘drug interaction’, ‘adverse-effects’, ‘side effects’, ‘adverse drug reaction’, ‘safety’, and ‘toxicity’ to identify relevant articles. Results: A total of 250 articles was identified, and these articles were checked in terms of title, abstract, and content according to inclusion and exclusion criteria. Finally, 18 articles were included in the study. The khat use significantly interact with most drugs and may cause unpredictable pharmacological sequences. Conclusions: Healthcare providers suggest patients` khat abstinence during medication process. Future studies need to investigate the khat- clinical drugs interactions especially with chronic used drugs.https://jppres.com/jppres/pdf/vol9/jppres20.951_9.3.333.pdfcatha eduliscathinonedrug interactionsdrug metabolizing enzymeskhat |
| spellingShingle | Nabil Ahmed Albaser Abdel-Wahab H. Mohamad Mohammed Amood AL-Kamarany Khat-drug interactions: A systematic review Journal of Pharmacy & Pharmacognosy Research catha edulis cathinone drug interactions drug metabolizing enzymes khat |
| title | Khat-drug interactions: A systematic review |
| title_full | Khat-drug interactions: A systematic review |
| title_fullStr | Khat-drug interactions: A systematic review |
| title_full_unstemmed | Khat-drug interactions: A systematic review |
| title_short | Khat-drug interactions: A systematic review |
| title_sort | khat drug interactions a systematic review |
| topic | catha edulis cathinone drug interactions drug metabolizing enzymes khat |
| url | https://jppres.com/jppres/pdf/vol9/jppres20.951_9.3.333.pdf |
| work_keys_str_mv | AT nabilahmedalbaser khatdruginteractionsasystematicreview AT abdelwahabhmohamad khatdruginteractionsasystematicreview AT mohammedamoodalkamarany khatdruginteractionsasystematicreview |