Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements
Amino acids and peptides are known to bind metal ions, in some cases very strongly. There are only a few examples of exploiting this binding in sensors. The review covers the current literature on the interaction of peptides and metals and the electrochemistry of bound metal ions. Peptides may be co...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2001-08-01
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| Series: | Sensors |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1424-8220/1/3/75/ |
| _version_ | 1811185225307258880 |
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| author | Wenrong Yang D. Brynn Hibbert J. Justin Gooding |
| author_facet | Wenrong Yang D. Brynn Hibbert J. Justin Gooding |
| author_sort | Wenrong Yang |
| collection | DOAJ |
| description | Amino acids and peptides are known to bind metal ions, in some cases very strongly. There are only a few examples of exploiting this binding in sensors. The review covers the current literature on the interaction of peptides and metals and the electrochemistry of bound metal ions. Peptides may be covalently attached to surfaces. Of particular interest is the attachment to gold via sulfur linkages. Sulfur-containing peptides (eg cysteine) may be adsorbed directly, while any amino group can be covalently attached to a carboxylic acid-terminated thiol. Once at a surface, the possibility for using the attached peptide as a sensor for metal ions becomes realised. Results from the authors’ laboratory and elsewhere have shown the potential for selective monitoring of metal ions at ppt levels. Examples of the use of poly-aspartic acid and the copper binding peptide Gly-Gly-His for detecting copper ions are given. |
| first_indexed | 2024-04-11T13:25:46Z |
| format | Article |
| id | doaj.art-8433796903d24ec0b96f74a88aba2e96 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-11T13:25:46Z |
| publishDate | 2001-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-8433796903d24ec0b96f74a88aba2e962022-12-22T04:22:04ZengMDPI AGSensors1424-82202001-08-0113759010.3390/s10300075Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition ElementsWenrong YangD. Brynn HibbertJ. Justin GoodingAmino acids and peptides are known to bind metal ions, in some cases very strongly. There are only a few examples of exploiting this binding in sensors. The review covers the current literature on the interaction of peptides and metals and the electrochemistry of bound metal ions. Peptides may be covalently attached to surfaces. Of particular interest is the attachment to gold via sulfur linkages. Sulfur-containing peptides (eg cysteine) may be adsorbed directly, while any amino group can be covalently attached to a carboxylic acid-terminated thiol. Once at a surface, the possibility for using the attached peptide as a sensor for metal ions becomes realised. Results from the authors’ laboratory and elsewhere have shown the potential for selective monitoring of metal ions at ppt levels. Examples of the use of poly-aspartic acid and the copper binding peptide Gly-Gly-His for detecting copper ions are given.http://www.mdpi.com/1424-8220/1/3/75/Metal ion sensorsAmino acidsPeptidesElectrochemistry |
| spellingShingle | Wenrong Yang D. Brynn Hibbert J. Justin Gooding Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements Sensors Metal ion sensors Amino acids Peptides Electrochemistry |
| title | Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements |
| title_full | Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements |
| title_fullStr | Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements |
| title_full_unstemmed | Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements |
| title_short | Electrochemical Metal Ion Sensors. Exploiting Amino Acids and Peptides as Recognition Elements |
| title_sort | electrochemical metal ion sensors exploiting amino acids and peptides as recognition elements |
| topic | Metal ion sensors Amino acids Peptides Electrochemistry |
| url | http://www.mdpi.com/1424-8220/1/3/75/ |
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