Long Non-Coding RNA MEG3 in Cellular Stemness
Long non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This revie...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/10/5348 |
| _version_ | 1797533490972983296 |
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| author | Pei-Fang Hsieh Cheng-Chia Yu Pei-Ming Chu Pei-Ling Hsieh |
| author_facet | Pei-Fang Hsieh Cheng-Chia Yu Pei-Ming Chu Pei-Ling Hsieh |
| author_sort | Pei-Fang Hsieh |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This review focuses on the molecular mechanisms by which lncRNA MEG3 functions as a signal, scaffold, guide, and decoy for multi-lineage differentiation and even cancer progression. The role of MEG3 in various types of stem cells and cancer stem cells is discussed. Here, we provide an overview of the functional versatility of lncRNA MEG3 in modulating pluripotency, differentiation, and cancer stemness. |
| first_indexed | 2024-03-10T11:16:16Z |
| format | Article |
| id | doaj.art-8433873fa07248ac8350e71119bb4179 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:16:16Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8433873fa07248ac8350e71119bb41792023-11-21T20:25:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012210534810.3390/ijms22105348Long Non-Coding RNA MEG3 in Cellular StemnessPei-Fang Hsieh0Cheng-Chia Yu1Pei-Ming Chu2Pei-Ling Hsieh3Department of Urology, E-Da Hospital, Kaohsiung 82445, TaiwanInstitute of Oral Sciences, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Anatomy, School of Medicine, China Medical University, Taichung 404333, TaiwanDepartment of Anatomy, School of Medicine, China Medical University, Taichung 404333, TaiwanLong non-coding RNAs (lncRNAs) regulate a diverse array of cellular processes at the transcriptional, post-transcriptional, translational, and post-translational levels. Accumulating evidence suggests that lncRNA MEG3 exerts a large repertoire of regulatory functions in cellular stemness. This review focuses on the molecular mechanisms by which lncRNA MEG3 functions as a signal, scaffold, guide, and decoy for multi-lineage differentiation and even cancer progression. The role of MEG3 in various types of stem cells and cancer stem cells is discussed. Here, we provide an overview of the functional versatility of lncRNA MEG3 in modulating pluripotency, differentiation, and cancer stemness.https://www.mdpi.com/1422-0067/22/10/5348long non-coding RNA MEG3embryonic stem cellsmesenchymal stem cellscancer stem cells |
| spellingShingle | Pei-Fang Hsieh Cheng-Chia Yu Pei-Ming Chu Pei-Ling Hsieh Long Non-Coding RNA MEG3 in Cellular Stemness International Journal of Molecular Sciences long non-coding RNA MEG3 embryonic stem cells mesenchymal stem cells cancer stem cells |
| title | Long Non-Coding RNA MEG3 in Cellular Stemness |
| title_full | Long Non-Coding RNA MEG3 in Cellular Stemness |
| title_fullStr | Long Non-Coding RNA MEG3 in Cellular Stemness |
| title_full_unstemmed | Long Non-Coding RNA MEG3 in Cellular Stemness |
| title_short | Long Non-Coding RNA MEG3 in Cellular Stemness |
| title_sort | long non coding rna meg3 in cellular stemness |
| topic | long non-coding RNA MEG3 embryonic stem cells mesenchymal stem cells cancer stem cells |
| url | https://www.mdpi.com/1422-0067/22/10/5348 |
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