Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs
ObjectivesTo investigate the intraoperative identification and complete resection of pulmonary masses, and to evaluate lymph node metastasis of pulmonary malignant tumors in dogs using indocyanine green (ICG) fluorescence imaging.MethodsForty dogs with pulmonary masses were included, all of which un...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1018263/full |
| _version_ | 1811170133878505472 |
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| author | Naoki Sakurai Kumiko Ishigaki Kazuyuki Terai Tatsuya Heishima Kazuki Okada Orie Yoshida Yumiko Kagawa Kazushi Asano |
| author_facet | Naoki Sakurai Kumiko Ishigaki Kazuyuki Terai Tatsuya Heishima Kazuki Okada Orie Yoshida Yumiko Kagawa Kazushi Asano |
| author_sort | Naoki Sakurai |
| collection | DOAJ |
| description | ObjectivesTo investigate the intraoperative identification and complete resection of pulmonary masses, and to evaluate lymph node metastasis of pulmonary malignant tumors in dogs using indocyanine green (ICG) fluorescence imaging.MethodsForty dogs with pulmonary masses were included, all of which underwent surgical treatment. ICG fluorescence imaging was performed on pulmonary masses before lobectomy and the resection margins after lobectomy. In addition, ICG fluorescence of the excised masses and lymph nodes was evaluated in the shaded box. The fluorescence findings were compared with the histopathological diagnosis.ResultsOf 44 nodules resected from 40 dogs, 32 nodules were histopathologically diagnosed as lung adenocarcinoma, five were histiocytic sarcoma, three were undifferentiated sarcoma, two were malignant epithelial tumor metastases, one was carcinosarcoma, and one was a non-neoplastic lesion. Fluorescence was observed in all nodules. In addition to the main lesion, other fluorescent nodules were found in four dogs. Regarding the diagnostic accuracy of complete resection based on ICG fluorescence, the sensitivity was 67.7% and the specificity was 60.0%. The sensitivity and specificity of ICG fluorescence for the diagnosis of lymph node metastasis were 100 and 75.0%, respectively.ConclusionsICG fluorescence imaging might be a useful intraoperative diagnostic method to identify the location of tumors and lymph node metastasis, but not to evaluate complete tumor resection, in dogs with pulmonary malignant tumors. |
| first_indexed | 2024-04-10T16:53:11Z |
| format | Article |
| id | doaj.art-8433bc07768d4794a086287ebd215bd2 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-10T16:53:11Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-8433bc07768d4794a086287ebd215bd22023-02-07T11:51:35ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-02-011010.3389/fvets.2023.10182631018263Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogsNaoki Sakurai0Kumiko Ishigaki1Kazuyuki Terai2Tatsuya Heishima3Kazuki Okada4Orie Yoshida5Yumiko Kagawa6Kazushi Asano7Laboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, JapanLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, JapanLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, JapanLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, JapanNorth Lab, Sapporo, JapanLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, JapanNorth Lab, Sapporo, JapanLaboratory of Veterinary Surgery, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, JapanObjectivesTo investigate the intraoperative identification and complete resection of pulmonary masses, and to evaluate lymph node metastasis of pulmonary malignant tumors in dogs using indocyanine green (ICG) fluorescence imaging.MethodsForty dogs with pulmonary masses were included, all of which underwent surgical treatment. ICG fluorescence imaging was performed on pulmonary masses before lobectomy and the resection margins after lobectomy. In addition, ICG fluorescence of the excised masses and lymph nodes was evaluated in the shaded box. The fluorescence findings were compared with the histopathological diagnosis.ResultsOf 44 nodules resected from 40 dogs, 32 nodules were histopathologically diagnosed as lung adenocarcinoma, five were histiocytic sarcoma, three were undifferentiated sarcoma, two were malignant epithelial tumor metastases, one was carcinosarcoma, and one was a non-neoplastic lesion. Fluorescence was observed in all nodules. In addition to the main lesion, other fluorescent nodules were found in four dogs. Regarding the diagnostic accuracy of complete resection based on ICG fluorescence, the sensitivity was 67.7% and the specificity was 60.0%. The sensitivity and specificity of ICG fluorescence for the diagnosis of lymph node metastasis were 100 and 75.0%, respectively.ConclusionsICG fluorescence imaging might be a useful intraoperative diagnostic method to identify the location of tumors and lymph node metastasis, but not to evaluate complete tumor resection, in dogs with pulmonary malignant tumors.https://www.frontiersin.org/articles/10.3389/fvets.2023.1018263/fulldogfluorescenceindocyanine greenpulmonary masseslymph node |
| spellingShingle | Naoki Sakurai Kumiko Ishigaki Kazuyuki Terai Tatsuya Heishima Kazuki Okada Orie Yoshida Yumiko Kagawa Kazushi Asano Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs Frontiers in Veterinary Science dog fluorescence indocyanine green pulmonary masses lymph node |
| title | Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs |
| title_full | Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs |
| title_fullStr | Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs |
| title_full_unstemmed | Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs |
| title_short | Impact of near-infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs |
| title_sort | impact of near infrared fluorescence imaging with indocyanine green on the surgical treatment of pulmonary masses in dogs |
| topic | dog fluorescence indocyanine green pulmonary masses lymph node |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1018263/full |
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