18F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis
Introduction A substantial proportion of patients who undergo surgery for drug resistant focal epilepsy do not become seizure free. While some factors, such as the detection of hippocampal sclerosis or a resectable lesion on MRI and electroencephalogram-MRI concordance, can predict favourable outcom...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/10/e065440.full |
| _version_ | 1811250431043567616 |
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| author | Lucy Vivash Patrick Kwan Terence J O'Brien Ana Antonic-Baker John-Paul Nicolo Benjamin Sinclair Andrew Neal Meng Law Merran R Courtney |
| author_facet | Lucy Vivash Patrick Kwan Terence J O'Brien Ana Antonic-Baker John-Paul Nicolo Benjamin Sinclair Andrew Neal Meng Law Merran R Courtney |
| author_sort | Lucy Vivash |
| collection | DOAJ |
| description | Introduction A substantial proportion of patients who undergo surgery for drug resistant focal epilepsy do not become seizure free. While some factors, such as the detection of hippocampal sclerosis or a resectable lesion on MRI and electroencephalogram-MRI concordance, can predict favourable outcomes in epilepsy surgery, the prognostic value of the detection of focal hypometabolism with 18F-fluorodeoxyglucose positive emission tomography (18F-FDG-PET) hypometabolism is uncertain. We propose a protocol for a systematic review and meta-analysis to examine whether localisation with 18F-FDG-PET hypometabolism predicts favourable outcomes in epilepsy surgery.Methods and analysis A systematic literature search of Medline, Embase and Web of Science will be undertaken. Publications which include evaluation with 18F-FDG-PET prior to surgery for drug resistant focal epilepsy, and which report ≥12 months of postoperative surgical outcome data will be included. Non-human, non-English language publications, publications with fewer than 10 participants and unpublished data will be excluded. Screening and full-text review of publications for inclusion will be undertaken by two independent investigators, with discrepancies resolved by consensus or a third investigator. Data will be extracted and pooled using random effects meta-analysis, with heterogeneity quantified using the I2 analysis.Ethics and dissemination Ethics approval is not required. Once complete, the systematic review will be published in a peer-reviewed journal.PROSPERO registration number CRD42022324823. |
| first_indexed | 2024-04-12T16:04:33Z |
| format | Article |
| id | doaj.art-843487984be2471593a54c9aed59001a |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-12T16:04:33Z |
| publishDate | 2022-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-843487984be2471593a54c9aed59001a2022-12-22T03:26:06ZengBMJ Publishing GroupBMJ Open2044-60552022-10-01121010.1136/bmjopen-2022-06544018F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysisLucy Vivash0Patrick Kwan1Terence J O'Brien2Ana Antonic-Baker3John-Paul Nicolo4Benjamin Sinclair5Andrew Neal6Meng Law7Merran R Courtney8Department of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaDepartment of Neuroscience, Monash University Central Clinical School, Melbourne, Victoria, AustraliaIntroduction A substantial proportion of patients who undergo surgery for drug resistant focal epilepsy do not become seizure free. While some factors, such as the detection of hippocampal sclerosis or a resectable lesion on MRI and electroencephalogram-MRI concordance, can predict favourable outcomes in epilepsy surgery, the prognostic value of the detection of focal hypometabolism with 18F-fluorodeoxyglucose positive emission tomography (18F-FDG-PET) hypometabolism is uncertain. We propose a protocol for a systematic review and meta-analysis to examine whether localisation with 18F-FDG-PET hypometabolism predicts favourable outcomes in epilepsy surgery.Methods and analysis A systematic literature search of Medline, Embase and Web of Science will be undertaken. Publications which include evaluation with 18F-FDG-PET prior to surgery for drug resistant focal epilepsy, and which report ≥12 months of postoperative surgical outcome data will be included. Non-human, non-English language publications, publications with fewer than 10 participants and unpublished data will be excluded. Screening and full-text review of publications for inclusion will be undertaken by two independent investigators, with discrepancies resolved by consensus or a third investigator. Data will be extracted and pooled using random effects meta-analysis, with heterogeneity quantified using the I2 analysis.Ethics and dissemination Ethics approval is not required. Once complete, the systematic review will be published in a peer-reviewed journal.PROSPERO registration number CRD42022324823.https://bmjopen.bmj.com/content/12/10/e065440.full |
| spellingShingle | Lucy Vivash Patrick Kwan Terence J O'Brien Ana Antonic-Baker John-Paul Nicolo Benjamin Sinclair Andrew Neal Meng Law Merran R Courtney 18F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis BMJ Open |
| title | 18F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis |
| title_full | 18F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis |
| title_fullStr | 18F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis |
| title_full_unstemmed | 18F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis |
| title_short | 18F-FDG-PET hypometabolism as a predictor of favourable outcome in epilepsy surgery: protocol for a systematic review and meta-analysis |
| title_sort | 18f fdg pet hypometabolism as a predictor of favourable outcome in epilepsy surgery protocol for a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/12/10/e065440.full |
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