Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents
Adolescent-onset depression is a prevalent and debilitating condition commonly associated with treatment refractory depression and non-response to first-line antidepressants. There are, however, no objective tests to determine who may or may not respond to antidepressants. As depressed adolescents a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354623001321 |
| _version_ | 1797350884221386752 |
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| author | Saché M. Coury Vanessa López Zia Bajwa Jordan M. Garcia Giana I. Teresi Kate R. Kuhlman Yan Li Steve Cole David J. Miklowitz Ioannis Pappas Tiffany C. Ho |
| author_facet | Saché M. Coury Vanessa López Zia Bajwa Jordan M. Garcia Giana I. Teresi Kate R. Kuhlman Yan Li Steve Cole David J. Miklowitz Ioannis Pappas Tiffany C. Ho |
| author_sort | Saché M. Coury |
| collection | DOAJ |
| description | Adolescent-onset depression is a prevalent and debilitating condition commonly associated with treatment refractory depression and non-response to first-line antidepressants. There are, however, no objective tests to determine who may or may not respond to antidepressants. As depressed adolescents are especially vulnerable to the lifelong consequences of ineffectively-treated depression, it is critical to identify neurobiological predictors of treatment non-response in this population. Here, we describe the scientific rationale and protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) study, a prospective 18-month investigation of 160 depressed adolescents who will be assessed before and after treatment with selective serotonin reuptake inhibitors. TIGER will be using ultra-high field imaging to test the effects of acute stress and antidepressant treatment on inflammatory and glutamatergic processes hypothesized to underlie depression maintenance. Results from this work will motivate future studies testing alternative therapeutics for depressed adolescents at risk for treatment resistant depression. ClinicalTrials.gov Identifier: NCT05329441. |
| first_indexed | 2024-03-08T12:51:33Z |
| format | Article |
| id | doaj.art-8435567304f943eb88a3dda02df5c12a |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-03-08T12:51:33Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-8435567304f943eb88a3dda02df5c12a2024-01-20T04:46:42ZengElsevierBrain, Behavior, & Immunity - Health2666-35462024-02-0135100718Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescentsSaché M. Coury0Vanessa López1Zia Bajwa2Jordan M. Garcia3Giana I. Teresi4Kate R. Kuhlman5Yan Li6Steve Cole7David J. Miklowitz8Ioannis Pappas9Tiffany C. Ho10Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USADepartment of Neuroscience, Columbia University, New York, NY, USADepartment of Psychiatry, Columnia University, New York, NY, USASchool of Social Work, University of Washington, Seattle, WA, USADepartment of Psychology, University of Pittsburgh, Pittsburgh, USADepartment of Psychological Science, School of Social Ecology, University of California Irvine, Irvine, CA, USA; Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USACousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA 90095, USA; Departments of Psychiatry and Biobehavioral Sciences and Medicine, Division of Hematology-Oncology, University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USALaboratory of NeuroImaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USADepartment of Psychology, University of California, Los Angeles, Los Angeles, CA, USA; Corresponding author.Department of Psychology University of California, 502 Portola Plaza Los Angeles, CA 90095, USAAdolescent-onset depression is a prevalent and debilitating condition commonly associated with treatment refractory depression and non-response to first-line antidepressants. There are, however, no objective tests to determine who may or may not respond to antidepressants. As depressed adolescents are especially vulnerable to the lifelong consequences of ineffectively-treated depression, it is critical to identify neurobiological predictors of treatment non-response in this population. Here, we describe the scientific rationale and protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) study, a prospective 18-month investigation of 160 depressed adolescents who will be assessed before and after treatment with selective serotonin reuptake inhibitors. TIGER will be using ultra-high field imaging to test the effects of acute stress and antidepressant treatment on inflammatory and glutamatergic processes hypothesized to underlie depression maintenance. Results from this work will motivate future studies testing alternative therapeutics for depressed adolescents at risk for treatment resistant depression. ClinicalTrials.gov Identifier: NCT05329441.http://www.sciencedirect.com/science/article/pii/S2666354623001321DepressionAdolescenceSocial stressFronto-cingulate-limbic circuitsMagnetic resonance spectroscopySelective serotonin reuptake inhibitors |
| spellingShingle | Saché M. Coury Vanessa López Zia Bajwa Jordan M. Garcia Giana I. Teresi Kate R. Kuhlman Yan Li Steve Cole David J. Miklowitz Ioannis Pappas Tiffany C. Ho Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents Brain, Behavior, & Immunity - Health Depression Adolescence Social stress Fronto-cingulate-limbic circuits Magnetic resonance spectroscopy Selective serotonin reuptake inhibitors |
| title | Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents |
| title_full | Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents |
| title_fullStr | Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents |
| title_full_unstemmed | Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents |
| title_short | Protocol for teen inflammation glutamate emotion research (TIGER): Toward predictors of treatment response and clinical course in depressed adolescents |
| title_sort | protocol for teen inflammation glutamate emotion research tiger toward predictors of treatment response and clinical course in depressed adolescents |
| topic | Depression Adolescence Social stress Fronto-cingulate-limbic circuits Magnetic resonance spectroscopy Selective serotonin reuptake inhibitors |
| url | http://www.sciencedirect.com/science/article/pii/S2666354623001321 |
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