Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, Iran
Background: Soil and plant contamination in copper exposure causes chronic copper poisoning (CCP) in animals following the consumption of plants in these soils. Objectives: The present study was carried out on 10 clinically affected copper poisoned cases (in each season) from autumn 2015 to the end...
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| Format: | Article |
| Language: | English |
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University of Tehran
2019-06-01
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| Series: | Iranian Journal of Veterinary Medicine |
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| Online Access: | https://ijvm.ut.ac.ir/article_71535_3767c440b6b511ebf6c7364425fa726b.pdf |
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| author | Seyyed Javad Afsah Hejri Khalil Badiei Mehrdad Pourjafar Ahmad Oryan Behnam Keshavarzi Aliasghar Chalmeh Gholamreza Mesbah |
| author_facet | Seyyed Javad Afsah Hejri Khalil Badiei Mehrdad Pourjafar Ahmad Oryan Behnam Keshavarzi Aliasghar Chalmeh Gholamreza Mesbah |
| author_sort | Seyyed Javad Afsah Hejri |
| collection | DOAJ |
| description | Background: Soil and plant contamination in copper exposure causes chronic copper poisoning (CCP) in animals following the consumption of plants in these soils. Objectives: The present study was carried out on 10 clinically affected copper poisoned cases (in each season) from autumn 2015 to the end of summer 2016, in four seasons in Kerman province to evaluate the seasonal effects of CCP in sheep. Methods: All samples were taken from clinically affected cases of copper poisoning that were then necropsied and the poisoning was confirmed by pathognomic pathological findings and serum copper concentration. Samples from liver, lung, kidney, heart and spleen were collected immediately after death and their copper concentration was measured. Results: The highest levels of copper in lung, heart, spleen and kidney were observed in the summer. Liver had the highest amounts of copper in spring and the levels of copper in wool and serum were detected in winter. The copper levels of liver and kidney were positively correlated in autumn, but the copper levels in these tissues were negatively correlated in both spring and winter. Conclusions: Severity of the copper toxicity (judged by the liver copper concentration) is season-dependent in sheep and seasonal variations affect this toxicity. Environmental climate and stressors may be the main causes of copper contents of different tissues and the liver is the main organ to reserve copper in poisoned sheep. |
| first_indexed | 2024-12-21T01:16:33Z |
| format | Article |
| id | doaj.art-8436fd49a9ab41d884011c8c3459aab8 |
| institution | Directory Open Access Journal |
| issn | 2251-8894 2252-0554 |
| language | English |
| last_indexed | 2024-12-21T01:16:33Z |
| publishDate | 2019-06-01 |
| publisher | University of Tehran |
| record_format | Article |
| series | Iranian Journal of Veterinary Medicine |
| spelling | doaj.art-8436fd49a9ab41d884011c8c3459aab82022-12-21T19:20:46ZengUniversity of TehranIranian Journal of Veterinary Medicine2251-88942252-05542019-06-0113216317310.22059/ijvm.2018.261446.100491171535Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, IranSeyyed Javad Afsah Hejri0Khalil Badiei1Mehrdad Pourjafar2Ahmad Oryan3Behnam Keshavarzi4Aliasghar Chalmeh5Gholamreza Mesbah6Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Comparative Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Environmental Geology, Shiraz University, Shiraz, IranDepartment of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, IranDepartment of Comparative Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, IranBackground: Soil and plant contamination in copper exposure causes chronic copper poisoning (CCP) in animals following the consumption of plants in these soils. Objectives: The present study was carried out on 10 clinically affected copper poisoned cases (in each season) from autumn 2015 to the end of summer 2016, in four seasons in Kerman province to evaluate the seasonal effects of CCP in sheep. Methods: All samples were taken from clinically affected cases of copper poisoning that were then necropsied and the poisoning was confirmed by pathognomic pathological findings and serum copper concentration. Samples from liver, lung, kidney, heart and spleen were collected immediately after death and their copper concentration was measured. Results: The highest levels of copper in lung, heart, spleen and kidney were observed in the summer. Liver had the highest amounts of copper in spring and the levels of copper in wool and serum were detected in winter. The copper levels of liver and kidney were positively correlated in autumn, but the copper levels in these tissues were negatively correlated in both spring and winter. Conclusions: Severity of the copper toxicity (judged by the liver copper concentration) is season-dependent in sheep and seasonal variations affect this toxicity. Environmental climate and stressors may be the main causes of copper contents of different tissues and the liver is the main organ to reserve copper in poisoned sheep.https://ijvm.ut.ac.ir/article_71535_3767c440b6b511ebf6c7364425fa726b.pdfcopper poisoningserumtissueseasonsheep |
| spellingShingle | Seyyed Javad Afsah Hejri Khalil Badiei Mehrdad Pourjafar Ahmad Oryan Behnam Keshavarzi Aliasghar Chalmeh Gholamreza Mesbah Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, Iran Iranian Journal of Veterinary Medicine copper poisoning serum tissue season sheep |
| title | Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, Iran |
| title_full | Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, Iran |
| title_fullStr | Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, Iran |
| title_full_unstemmed | Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, Iran |
| title_short | Seasonal Variation and Relationships Between Copper of Serum and Various Tissues in Copper Poisoned Sheep in Kerman Province, Iran |
| title_sort | seasonal variation and relationships between copper of serum and various tissues in copper poisoned sheep in kerman province iran |
| topic | copper poisoning serum tissue season sheep |
| url | https://ijvm.ut.ac.ir/article_71535_3767c440b6b511ebf6c7364425fa726b.pdf |
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