Optimization of Chromatographic Conditions with QbD for Method Development and Validation of Bosutinib by HPLC: Applications in Dosage Forms and Rat Plasma Analysis

Optimization of Chromatographic Conditions with QbD for Method Development and Validation of Bosutinib by HPLC: Applications in Dosage Forms and Rat Plasma Analysis

Aim: Bosutinib (BST) is an anti-cancer medicine that is used to treat a variety of different types of cancer. Using the HPLC method of analysis and the Quality by Design (QbD) strategy, the study aimed to precisely quantify the drug in tablet form and in rat plasma. Methodology: For the developed me...

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Bibliographic Details
Main Authors: Asim Najmi, Zia ur Rehman, Hassan Ahmed Alhazmi, Mohammed Mofarreh Albratty, Nasser Hassan Majrashi, Khalid Mohammed Hakami, Naif Ali Najmi, Ammar Abdullah Mobarki
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Separations
Subjects:
Bosutinib
Box–Behnken Design (BBD)
dosage form
independent variables
method validation
rat plasma
Online Access:https://www.mdpi.com/2297-8739/10/6/346

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https://www.mdpi.com/2297-8739/10/6/346

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