Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses
Human oncogenic viruses are a group of important pathogens that etiologically contribute to at least 12% of total cancer cases in the world. As an emerging class of non-linear regulatory RNA molecules, circular RNAs (circRNAs) have gained increasing attention as a crucial player in the regulation of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.657036/full |
| _version_ | 1818921561271304192 |
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| author | Janardhan Avilala David Becnel Ramsy Abdelghani Asuka Nanbo Jacob Kahn Li Li Zhen Lin |
| author_facet | Janardhan Avilala David Becnel Ramsy Abdelghani Asuka Nanbo Jacob Kahn Li Li Zhen Lin |
| author_sort | Janardhan Avilala |
| collection | DOAJ |
| description | Human oncogenic viruses are a group of important pathogens that etiologically contribute to at least 12% of total cancer cases in the world. As an emerging class of non-linear regulatory RNA molecules, circular RNAs (circRNAs) have gained increasing attention as a crucial player in the regulation of signaling pathways involved in viral infection and oncogenesis. With the assistance of current circRNA enrichment and detection technologies, numerous novel virally-encoded circRNAs (vcircRNAs) have been identified in the human oncogenic viruses, initiating an exciting new era of vcircRNA research. In this review, we discuss the current understanding of the roles of vcircRNAs in the respective viral infection cycles and in virus-associated pathogenesis. |
| first_indexed | 2024-12-20T01:39:36Z |
| format | Article |
| id | doaj.art-8439b08d210a4de79144519a30f08ca8 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T01:39:36Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-8439b08d210a4de79144519a30f08ca82022-12-21T19:57:56ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-04-011210.3389/fmicb.2021.657036657036Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic VirusesJanardhan Avilala0David Becnel1Ramsy Abdelghani2Asuka Nanbo3Jacob Kahn4Li Li5Zhen Lin6Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA, United StatesDepartment of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United StatesDepartment of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United StatesNational Research Center for the Control and Prevention of Infectious Diseases, Nagasaki University, Nagasaki, JapanTulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA, United StatesInstitute of Translational Research, Ochsner Clinic Foundation, New Orleans, LA, United StatesTulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA, United StatesHuman oncogenic viruses are a group of important pathogens that etiologically contribute to at least 12% of total cancer cases in the world. As an emerging class of non-linear regulatory RNA molecules, circular RNAs (circRNAs) have gained increasing attention as a crucial player in the regulation of signaling pathways involved in viral infection and oncogenesis. With the assistance of current circRNA enrichment and detection technologies, numerous novel virally-encoded circRNAs (vcircRNAs) have been identified in the human oncogenic viruses, initiating an exciting new era of vcircRNA research. In this review, we discuss the current understanding of the roles of vcircRNAs in the respective viral infection cycles and in virus-associated pathogenesis.https://www.frontiersin.org/articles/10.3389/fmicb.2021.657036/fullcircular RNAcircRNAoncogenic virusEBVKSHVHPV |
| spellingShingle | Janardhan Avilala David Becnel Ramsy Abdelghani Asuka Nanbo Jacob Kahn Li Li Zhen Lin Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses Frontiers in Microbiology circular RNA circRNA oncogenic virus EBV KSHV HPV |
| title | Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses |
| title_full | Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses |
| title_fullStr | Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses |
| title_full_unstemmed | Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses |
| title_short | Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses |
| title_sort | role of virally encoded circular rnas in the pathogenicity of human oncogenic viruses |
| topic | circular RNA circRNA oncogenic virus EBV KSHV HPV |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.657036/full |
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