Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial
Chronic pain affects mental and physical health and alters brain structure and function. Interventions that reduce chronic pain are also associated with changes in the brain. A number of non-invasive strategies can promote improved learning and memory and increase neuroplasticity in older adults. In...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/5/1556 |
| _version_ | 1797535225447710720 |
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| author | Steven Pratscher Angela M. Mickle John G. Marks Harold Rocha Felix Bartsch Jeffrey Schmidt Lazaro Tejera Steven Garcia Carlo Custodero Federlin Jean Cynthia Garvan Alisa J. Johnson Ralisa Pop Anthony Greene Adam J. Woods Roland Staud Roger B. Fillingim Andreas Keil Kimberly T. Sibille |
| author_facet | Steven Pratscher Angela M. Mickle John G. Marks Harold Rocha Felix Bartsch Jeffrey Schmidt Lazaro Tejera Steven Garcia Carlo Custodero Federlin Jean Cynthia Garvan Alisa J. Johnson Ralisa Pop Anthony Greene Adam J. Woods Roland Staud Roger B. Fillingim Andreas Keil Kimberly T. Sibille |
| author_sort | Steven Pratscher |
| collection | DOAJ |
| description | Chronic pain affects mental and physical health and alters brain structure and function. Interventions that reduce chronic pain are also associated with changes in the brain. A number of non-invasive strategies can promote improved learning and memory and increase neuroplasticity in older adults. Intermittent fasting and glucose administration represent two such strategies with the potential to optimize the neurobiological environment to increase responsiveness to recognized pain treatments. The purpose of the pilot study was to test the feasibility and acceptability of intermittent fasting and glucose administration paired with a recognized pain treatment activity, relaxation and guided imagery. A total of 32 adults (44% W, 56% M), 50 to 85 years of age, with chronic knee pain for three months or greater participated in the study. Four sessions were completed over an approximate two-week period. Findings indicate the ability to recruit, randomize, and retain participants in the protocol. The procedures and measures were reasonable and completed without incident. Participant adherence was high and exit interview feedback positive. In summary, the pilot study was feasible and acceptable, providing the evidence necessary to move forward with a larger clinical trial. |
| first_indexed | 2024-03-10T11:41:30Z |
| format | Article |
| id | doaj.art-8439f74ec00f4b3294b3d2f7752a9a3d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T11:41:30Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8439f74ec00f4b3294b3d2f7752a9a3d2023-11-21T18:26:44ZengMDPI AGNutrients2072-66432021-05-01135155610.3390/nu13051556Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled TrialSteven Pratscher0Angela M. Mickle1John G. Marks2Harold Rocha3Felix Bartsch4Jeffrey Schmidt5Lazaro Tejera6Steven Garcia7Carlo Custodero8Federlin Jean9Cynthia Garvan10Alisa J. Johnson11Ralisa Pop12Anthony Greene13Adam J. Woods14Roland Staud15Roger B. Fillingim16Andreas Keil17Kimberly T. Sibille18Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL 32611, USADepartment of Community of Dentistry, University of Florida, Gainesville, FL 32611, USAPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL 32611, USADepartment of Psychology, University of Florida, Gainesville, FL 32611, USADepartment of Psychology, University of Florida, Gainesville, FL 32611, USACollege of Health Professions and Sciences, University of Central Florida, Orlando, FL 32816, USADepartment of Interdisciplinary Medicine, University of Bari, 70125 Bari, ItalyDepartment of Psychology, University of Florida, Gainesville, FL 32611, USADepartment of Interdisciplinary Medicine, University of Bari, 70125 Bari, ItalyDepartment of Aging & Geriatric Research, University of Florida, Gainesville, FL 32611, USADepartment of Anesthesiology, University of Florida, Gainesville, FL 32611, USAPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL 32611, USAPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL 32611, USACounseling and Wellness Center, University of Florida, Gainesville, FL 32611, USADepartment of Clinical and Health Psychology, Center for Cognitive Aging and Memory Clinical Translational Research, University of Florida, Gainesville, FL 32611, USADepartment of Medicine, University of Florida, Gainesville, FL 32611, USAPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL 32611, USADepartment of Psychology, University of Florida, Gainesville, FL 32611, USAPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL 32611, USAChronic pain affects mental and physical health and alters brain structure and function. Interventions that reduce chronic pain are also associated with changes in the brain. A number of non-invasive strategies can promote improved learning and memory and increase neuroplasticity in older adults. Intermittent fasting and glucose administration represent two such strategies with the potential to optimize the neurobiological environment to increase responsiveness to recognized pain treatments. The purpose of the pilot study was to test the feasibility and acceptability of intermittent fasting and glucose administration paired with a recognized pain treatment activity, relaxation and guided imagery. A total of 32 adults (44% W, 56% M), 50 to 85 years of age, with chronic knee pain for three months or greater participated in the study. Four sessions were completed over an approximate two-week period. Findings indicate the ability to recruit, randomize, and retain participants in the protocol. The procedures and measures were reasonable and completed without incident. Participant adherence was high and exit interview feedback positive. In summary, the pilot study was feasible and acceptable, providing the evidence necessary to move forward with a larger clinical trial.https://www.mdpi.com/2072-6643/13/5/1556chronic painneuroplasticityintermittent fastingglucoseosteoarthritisnon-invasive interventions |
| spellingShingle | Steven Pratscher Angela M. Mickle John G. Marks Harold Rocha Felix Bartsch Jeffrey Schmidt Lazaro Tejera Steven Garcia Carlo Custodero Federlin Jean Cynthia Garvan Alisa J. Johnson Ralisa Pop Anthony Greene Adam J. Woods Roland Staud Roger B. Fillingim Andreas Keil Kimberly T. Sibille Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial Nutrients chronic pain neuroplasticity intermittent fasting glucose osteoarthritis non-invasive interventions |
| title | Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial |
| title_full | Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial |
| title_fullStr | Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial |
| title_full_unstemmed | Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial |
| title_short | Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial |
| title_sort | optimizing chronic pain treatment with enhanced neuroplastic responsiveness a pilot randomized controlled trial |
| topic | chronic pain neuroplasticity intermittent fasting glucose osteoarthritis non-invasive interventions |
| url | https://www.mdpi.com/2072-6643/13/5/1556 |
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