Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis

Metformin Exerts Anti-inflammatory and Mucus Barrier Protective Effects by Enriching Akkermansia muciniphila in Mice With Ulcerative Colitis

The present study aimed to determine if metformin exerts anti-inflammatory and mucus-protective effects via the gut microbiota. Metformin has extensive benefits including anti-inflammatory effects. Previous studies showed that metformin changed the gut microbiota composition and increases the number...

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Bibliographic Details
Main Authors: Haoran Ke, Fang Li, Wenlin Deng, Zitong Li, Siqi Wang, Pinjing Lv, Ye Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
intestinal barrier
inflammatory bowel diseases
probiotics
gut microbiota
mucin2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.726707/full

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