Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation
Vitamin D deficiency is prevalent in pediatric patients presenting for hematopoietic stem cell transplantation (HSCT) and has been linked to poor clinical outcomes. Using the data from a randomized control trial, in this paper we explore the effects of vitamin D supplementation on circulating cytoki...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.913586/full |
| _version_ | 1818532517820497920 |
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| author | Braden Olsen Jessica Bodea Angela Garcia Kristen Beebe Kristen Beebe Courtney Campbell Carly Schwalbach Dana Salzberg Holly Miller Roberta Adams Roberta Adams Lucia Mirea Paul Castillo Biljana Horn Sandhya Bansal Thalachallour Mohanakumar Alexander Ngwube Alexander Ngwube Alexander Ngwube |
| author_facet | Braden Olsen Jessica Bodea Angela Garcia Kristen Beebe Kristen Beebe Courtney Campbell Carly Schwalbach Dana Salzberg Holly Miller Roberta Adams Roberta Adams Lucia Mirea Paul Castillo Biljana Horn Sandhya Bansal Thalachallour Mohanakumar Alexander Ngwube Alexander Ngwube Alexander Ngwube |
| author_sort | Braden Olsen |
| collection | DOAJ |
| description | Vitamin D deficiency is prevalent in pediatric patients presenting for hematopoietic stem cell transplantation (HSCT) and has been linked to poor clinical outcomes. Using the data from a randomized control trial, in this paper we explore the effects of vitamin D supplementation on circulating cytokine levels during pediatric HSCT (www.clinicaltrials.gov as NCT03176849). A total of 41 children, 20 received Stoss therapy and 21 children received standard of care vitamin D supplementation. Levels of 25(OH)D and 20 cytokines were assessed at baseline and day +30. Significantly (P < 0.05) higher levels of mostly proinflammatory cytokines, FGF, GCSF, TNFα, IL-2, IL-6, IP10 were detected pre-transplant for patients with low compared to those with normal vitamin D levels. In sex stratified models that compare changes in cytokines between Stoss vs. standard of care, females in the Stoss group show greater changes in mostly pro -inflammatory cytokines- IP-10 (P = 0.0047), MIG (P = 0.009), and RANTES (P = 0.0047), IL-2R (P = 0.07) and IL-6(P = 0.069). Despite a small sample size, these findings suggest vitamin D deficiency affects the pre-transplant cytokine milieu and higher doses of vitamin D (Stoss therapy) appears to influence proinflammatory cytokine responses in a sex specific manner during pediatric HSCT. Larger clinical trials are warranted to validate these results. |
| first_indexed | 2024-12-11T17:46:34Z |
| format | Article |
| id | doaj.art-843e3963374d4189826745510bb40f68 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-11T17:46:34Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-843e3963374d4189826745510bb40f682022-12-22T00:56:21ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-07-011010.3389/fped.2022.913586913586Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell TransplantationBraden Olsen0Jessica Bodea1Angela Garcia2Kristen Beebe3Kristen Beebe4Courtney Campbell5Carly Schwalbach6Dana Salzberg7Holly Miller8Roberta Adams9Roberta Adams10Lucia Mirea11Paul Castillo12Biljana Horn13Sandhya Bansal14Thalachallour Mohanakumar15Alexander Ngwube16Alexander Ngwube17Alexander Ngwube18Creighton School of Medicine, Phoenix, AZ, United StatesSt. Jude Children's Research Hospital, Memphis, TN, United StatesCreighton School of Medicine, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesMayo Clinic Arizona, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesMayo Clinic Arizona, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesUF Health Shands Children's Hospital, Gainesville, FL, United StatesUF Health Shands Children's Hospital, Gainesville, FL, United StatesSt. Joseph's Hospital & Medical Center, Phoenix, AZ, United StatesSt. Joseph's Hospital & Medical Center, Phoenix, AZ, United StatesCreighton School of Medicine, Phoenix, AZ, United StatesPhoenix Children's Hospital, Phoenix, AZ, United StatesMayo Clinic Arizona, Phoenix, AZ, United StatesVitamin D deficiency is prevalent in pediatric patients presenting for hematopoietic stem cell transplantation (HSCT) and has been linked to poor clinical outcomes. Using the data from a randomized control trial, in this paper we explore the effects of vitamin D supplementation on circulating cytokine levels during pediatric HSCT (www.clinicaltrials.gov as NCT03176849). A total of 41 children, 20 received Stoss therapy and 21 children received standard of care vitamin D supplementation. Levels of 25(OH)D and 20 cytokines were assessed at baseline and day +30. Significantly (P < 0.05) higher levels of mostly proinflammatory cytokines, FGF, GCSF, TNFα, IL-2, IL-6, IP10 were detected pre-transplant for patients with low compared to those with normal vitamin D levels. In sex stratified models that compare changes in cytokines between Stoss vs. standard of care, females in the Stoss group show greater changes in mostly pro -inflammatory cytokines- IP-10 (P = 0.0047), MIG (P = 0.009), and RANTES (P = 0.0047), IL-2R (P = 0.07) and IL-6(P = 0.069). Despite a small sample size, these findings suggest vitamin D deficiency affects the pre-transplant cytokine milieu and higher doses of vitamin D (Stoss therapy) appears to influence proinflammatory cytokine responses in a sex specific manner during pediatric HSCT. Larger clinical trials are warranted to validate these results.https://www.frontiersin.org/articles/10.3389/fped.2022.913586/fullvitamin Dhematopoietic cell transplantationpediatriccytokine-immunological termstransplant complications |
| spellingShingle | Braden Olsen Jessica Bodea Angela Garcia Kristen Beebe Kristen Beebe Courtney Campbell Carly Schwalbach Dana Salzberg Holly Miller Roberta Adams Roberta Adams Lucia Mirea Paul Castillo Biljana Horn Sandhya Bansal Thalachallour Mohanakumar Alexander Ngwube Alexander Ngwube Alexander Ngwube Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation Frontiers in Pediatrics vitamin D hematopoietic cell transplantation pediatric cytokine-immunological terms transplant complications |
| title | Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation |
| title_full | Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation |
| title_fullStr | Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation |
| title_full_unstemmed | Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation |
| title_short | Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell Transplantation |
| title_sort | vitamin d supplementation association with serum cytokines in pediatric hematopoietic stem cell transplantation |
| topic | vitamin D hematopoietic cell transplantation pediatric cytokine-immunological terms transplant complications |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.913586/full |
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