How can childhood maltreatment affect post-traumatic stress disorder in adult: Results from a composite null hypothesis perspective of mediation analysis

How can childhood maltreatment affect post-traumatic stress disorder in adult: Results from a composite null hypothesis perspective of mediation analysis

BackgroundA greatly growing body of literature has revealed the mediating role of DNA methylation in the influence path from childhood maltreatment to psychiatric disorders such as post-traumatic stress disorder (PTSD) in adult. However, the statistical method is challenging and powerful mediation a...

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Bibliographic Details
Main Authors: Haibo Xu, Zhonghe Shao, Shuo Zhang, Xin Liu, Ping Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Psychiatry
Subjects:
DNA methylation
divide-aggregate composite-null hypothesis test
gene-based mediation analysis
childhood maltreatment
psychiatric disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1102811/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1102811/full

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