Cold but not too cold: advances in hypothermic and normothermic organ perfusion
Transplantation is the method of choice and, in many cases, the only method of treatment for patients with end-stage organ disease. Excellent results have been achieved, and the main focus today is to extend the number of available donors. The use of extended-criteria donors or donors after circulat...
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| Format: | Article |
| Language: | English |
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Korean Society for Transplantation
2022-03-01
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| Series: | Korean Journal of Transplantation |
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| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0008 |
| _version_ | 1827393847218405376 |
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| author | Guenter Kirste |
| author_facet | Guenter Kirste |
| author_sort | Guenter Kirste |
| collection | DOAJ |
| description | Transplantation is the method of choice and, in many cases, the only method of treatment for patients with end-stage organ disease. Excellent results have been achieved, and the main focus today is to extend the number of available donors. The use of extended-criteria donors or donors after circulatory death is standard, but is accompanied by an increased risk of ischemia reperfusion injury. This review presents newly developed machine perfusion techniques using hypothermic, subnormothermic, or normothermic conditions, with or without oxygenation. Possibilities for treatment and quality assessment in decision-making about organ acceptability are also discussed. |
| first_indexed | 2024-03-08T17:56:17Z |
| format | Article |
| id | doaj.art-84458351e9a74df4afc4fcf1475d7da9 |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T17:56:17Z |
| publishDate | 2022-03-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-84458351e9a74df4afc4fcf1475d7da92024-01-02T04:34:13ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902022-03-0136121410.4285/kjt.22.0008kjt.22.0008Cold but not too cold: advances in hypothermic and normothermic organ perfusionGuenter Kirste0Department of Surgery, University Hospital of Freiburg, Albert Ludwig University of Freiburg, Freiburg im Breisgau, GermanyTransplantation is the method of choice and, in many cases, the only method of treatment for patients with end-stage organ disease. Excellent results have been achieved, and the main focus today is to extend the number of available donors. The use of extended-criteria donors or donors after circulatory death is standard, but is accompanied by an increased risk of ischemia reperfusion injury. This review presents newly developed machine perfusion techniques using hypothermic, subnormothermic, or normothermic conditions, with or without oxygenation. Possibilities for treatment and quality assessment in decision-making about organ acceptability are also discussed.http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0008organ donation; organ protection; cold storage; normothermic machine perfusion; ischemic reperfusion injury |
| spellingShingle | Guenter Kirste Cold but not too cold: advances in hypothermic and normothermic organ perfusion Korean Journal of Transplantation organ donation; organ protection; cold storage; normothermic machine perfusion; ischemic reperfusion injury |
| title | Cold but not too cold: advances in hypothermic and normothermic organ perfusion |
| title_full | Cold but not too cold: advances in hypothermic and normothermic organ perfusion |
| title_fullStr | Cold but not too cold: advances in hypothermic and normothermic organ perfusion |
| title_full_unstemmed | Cold but not too cold: advances in hypothermic and normothermic organ perfusion |
| title_short | Cold but not too cold: advances in hypothermic and normothermic organ perfusion |
| title_sort | cold but not too cold advances in hypothermic and normothermic organ perfusion |
| topic | organ donation; organ protection; cold storage; normothermic machine perfusion; ischemic reperfusion injury |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/kjt.22.0008 |
| work_keys_str_mv | AT guenterkirste coldbutnottoocoldadvancesinhypothermicandnormothermicorganperfusion |