COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac Disease
(1) Background: COVID-19 vaccination campaigns offer the best hope of controlling the pandemic. However, the fast production of COVID-19 vaccines has caused concern among the general public regarding their safety and efficacy. In particular, patients with chronic illnesses, such as celiac disease (C...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/5/511 |
| _version_ | 1827692432181952512 |
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| author | Andrea Costantino Matilde Topa Leda Roncoroni Luisa Doneda Vincenza Lombardo Davide Stocco Andrea Gramegna Claudio Costantino Maurizio Vecchi Luca Elli |
| author_facet | Andrea Costantino Matilde Topa Leda Roncoroni Luisa Doneda Vincenza Lombardo Davide Stocco Andrea Gramegna Claudio Costantino Maurizio Vecchi Luca Elli |
| author_sort | Andrea Costantino |
| collection | DOAJ |
| description | (1) Background: COVID-19 vaccination campaigns offer the best hope of controlling the pandemic. However, the fast production of COVID-19 vaccines has caused concern among the general public regarding their safety and efficacy. In particular, patients with chronic illnesses, such as celiac disease (CD), may be more fearful. Information on vaccine hesitancy plays a pivotal role in the development of an efficient vaccination campaign. In our study, we aimed to evaluate COVID-19 vaccine hesitancy among Italian CD patients. (2) Methods: an anonymous questionnaire was sent to CD patients followed at our tertiary referral center for CD in Milan, Italy. Patients were defined as willing, hesitant and refusing. We evaluated the reasons for hesitancy/refusal and the possible determinants, calculating crude and adjusted odds ratios [AdjORs] with 95% confidence intervals [CIs]. (3) Results: the questionnaire was sent to 346 patients with a response rate of 29.8%. Twenty-six (25.2%) of the 103 respondents were hesitant, with a total refusal rate of 4.8%. The main reason was fear of adverse events related to vaccination (68.2%). Among hesitant patients, 23% declared that their opinion was influenced by their CD. The determinants positively influencing willingness to be vaccinated against COVID-19 were adherence to a GFD, perception of good knowledge about COVID-19 and its vaccines, and a positive attitude to previous vaccines (AdjOR 12.71, 95% CI 1.82–88.58, AdjOR 6.50, 95% CI 1.44–29.22, AdjOR 0.70, 95% CI 0.11–4.34, respectively). (4) Conclusions: CD patients should be vaccinated against COVID-19 and a specific campaign to address the determinants of hesitancy should be developed. |
| first_indexed | 2024-03-10T11:22:05Z |
| format | Article |
| id | doaj.art-84483f9f7f604a5d82f9917c8f2a21b0 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T11:22:05Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-84483f9f7f604a5d82f9917c8f2a21b02023-11-21T19:57:00ZengMDPI AGVaccines2076-393X2021-05-019551110.3390/vaccines9050511COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac DiseaseAndrea Costantino0Matilde Topa1Leda Roncoroni2Luisa Doneda3Vincenza Lombardo4Davide Stocco5Andrea Gramegna6Claudio Costantino7Maurizio Vecchi8Luca Elli9Gastroenterology and Endoscopy Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20214 Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, 20124 Milan, ItalyGastroenterology and Endoscopy Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20214 Milan, ItalyDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20124 Milan, ItalyGastroenterology and Endoscopy Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20214 Milan, ItalyDepartment of Mathematics, Politecnico di Milano, 20124 Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, 20124 Milan, ItalyDepartment of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Excellence Specialties “G. D’Alessandro”, University of Palermo, 90145 Palermo, ItalyGastroenterology and Endoscopy Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20214 Milan, ItalyGastroenterology and Endoscopy Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20214 Milan, Italy(1) Background: COVID-19 vaccination campaigns offer the best hope of controlling the pandemic. However, the fast production of COVID-19 vaccines has caused concern among the general public regarding their safety and efficacy. In particular, patients with chronic illnesses, such as celiac disease (CD), may be more fearful. Information on vaccine hesitancy plays a pivotal role in the development of an efficient vaccination campaign. In our study, we aimed to evaluate COVID-19 vaccine hesitancy among Italian CD patients. (2) Methods: an anonymous questionnaire was sent to CD patients followed at our tertiary referral center for CD in Milan, Italy. Patients were defined as willing, hesitant and refusing. We evaluated the reasons for hesitancy/refusal and the possible determinants, calculating crude and adjusted odds ratios [AdjORs] with 95% confidence intervals [CIs]. (3) Results: the questionnaire was sent to 346 patients with a response rate of 29.8%. Twenty-six (25.2%) of the 103 respondents were hesitant, with a total refusal rate of 4.8%. The main reason was fear of adverse events related to vaccination (68.2%). Among hesitant patients, 23% declared that their opinion was influenced by their CD. The determinants positively influencing willingness to be vaccinated against COVID-19 were adherence to a GFD, perception of good knowledge about COVID-19 and its vaccines, and a positive attitude to previous vaccines (AdjOR 12.71, 95% CI 1.82–88.58, AdjOR 6.50, 95% CI 1.44–29.22, AdjOR 0.70, 95% CI 0.11–4.34, respectively). (4) Conclusions: CD patients should be vaccinated against COVID-19 and a specific campaign to address the determinants of hesitancy should be developed.https://www.mdpi.com/2076-393X/9/5/511COVID-19 vaccinesCOVID-19vaccine hesitancyceliac diseasevaccines |
| spellingShingle | Andrea Costantino Matilde Topa Leda Roncoroni Luisa Doneda Vincenza Lombardo Davide Stocco Andrea Gramegna Claudio Costantino Maurizio Vecchi Luca Elli COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac Disease Vaccines COVID-19 vaccines COVID-19 vaccine hesitancy celiac disease vaccines |
| title | COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac Disease |
| title_full | COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac Disease |
| title_fullStr | COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac Disease |
| title_full_unstemmed | COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac Disease |
| title_short | COVID-19 Vaccine: A Survey of Hesitancy in Patients with Celiac Disease |
| title_sort | covid 19 vaccine a survey of hesitancy in patients with celiac disease |
| topic | COVID-19 vaccines COVID-19 vaccine hesitancy celiac disease vaccines |
| url | https://www.mdpi.com/2076-393X/9/5/511 |
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