Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction
Background: Recently, the nutritional status of patients has drawn attention in an aging society. Early studies have reported that nutritional status is related to long-term outcomes in patients with acute myocardial infarction (AMI). However, it is not necessarily simple to evaluate the nutritional...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/19/6134 |
| _version_ | 1797575692270960640 |
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| author | Shun Ishibashi Kenichi Sakakura Tomoya Ikeda Yousuke Taniguchi Hiroyuki Jinnouchi Takunori Tsukui Yusuke Watanabe Masashi Hatori Kei Yamamoto Masaru Seguchi Hideo Fujita |
| author_facet | Shun Ishibashi Kenichi Sakakura Tomoya Ikeda Yousuke Taniguchi Hiroyuki Jinnouchi Takunori Tsukui Yusuke Watanabe Masashi Hatori Kei Yamamoto Masaru Seguchi Hideo Fujita |
| author_sort | Shun Ishibashi |
| collection | DOAJ |
| description | Background: Recently, the nutritional status of patients has drawn attention in an aging society. Early studies have reported that nutritional status is related to long-term outcomes in patients with acute myocardial infarction (AMI). However, it is not necessarily simple to evaluate the nutritional status of patients with AMI. We hypothesized that appetite before discharge can be a predictor for long-term adverse cardiovascular events in patients with AMI. This retrospective study aimed to investigate whether appetite is related to long-term adverse outcomes in patients with AMI. Methods: This study included 1006 patients with AMI, and divided them into the good appetite group (<i>n</i> = 860) and the poor appetite group (<i>n</i> = 146) according to the percentage of the dietary intake on the day before discharge. Major adverse cardiac events (MACE), which were defined as a composite of all-cause death, non-fatal MI, and re-admission for heart failure, were set as the primary outcome. Results: The median follow-up duration was 996 days, and a total of 243 MACE was observed during the study period. MACE was more frequently observed in the poor appetite group than in the good appetite group (42.5% versus 21.0%, <i>p</i> < 0.001). In the multivariate COX hazard model, poor appetite was significantly associated with MACE (Hazard ratio 1.698, 95% confidence interval 1.243–2.319, <i>p</i> < 0.001) after controlling for multiple confounding factors. Conclusion: Appetite at the time of discharge was significantly associated with long-term clinical outcomes in patients with AMI. Patients with poor appetite should be carefully followed up after discharge from AMI. |
| first_indexed | 2024-03-10T21:42:51Z |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T21:42:51Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-844b5b1cb2f448a18683162ec89e85c52023-11-19T14:34:34ZengMDPI AGJournal of Clinical Medicine2077-03832023-09-011219613410.3390/jcm12196134Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial InfarctionShun Ishibashi0Kenichi Sakakura1Tomoya Ikeda2Yousuke Taniguchi3Hiroyuki Jinnouchi4Takunori Tsukui5Yusuke Watanabe6Masashi Hatori7Kei Yamamoto8Masaru Seguchi9Hideo Fujita10Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya, Saitama City 330-8503, JapanBackground: Recently, the nutritional status of patients has drawn attention in an aging society. Early studies have reported that nutritional status is related to long-term outcomes in patients with acute myocardial infarction (AMI). However, it is not necessarily simple to evaluate the nutritional status of patients with AMI. We hypothesized that appetite before discharge can be a predictor for long-term adverse cardiovascular events in patients with AMI. This retrospective study aimed to investigate whether appetite is related to long-term adverse outcomes in patients with AMI. Methods: This study included 1006 patients with AMI, and divided them into the good appetite group (<i>n</i> = 860) and the poor appetite group (<i>n</i> = 146) according to the percentage of the dietary intake on the day before discharge. Major adverse cardiac events (MACE), which were defined as a composite of all-cause death, non-fatal MI, and re-admission for heart failure, were set as the primary outcome. Results: The median follow-up duration was 996 days, and a total of 243 MACE was observed during the study period. MACE was more frequently observed in the poor appetite group than in the good appetite group (42.5% versus 21.0%, <i>p</i> < 0.001). In the multivariate COX hazard model, poor appetite was significantly associated with MACE (Hazard ratio 1.698, 95% confidence interval 1.243–2.319, <i>p</i> < 0.001) after controlling for multiple confounding factors. Conclusion: Appetite at the time of discharge was significantly associated with long-term clinical outcomes in patients with AMI. Patients with poor appetite should be carefully followed up after discharge from AMI.https://www.mdpi.com/2077-0383/12/19/6134percutaneous coronary interventionacute myocardial infarctionappetitemajor adverse cardiac events |
| spellingShingle | Shun Ishibashi Kenichi Sakakura Tomoya Ikeda Yousuke Taniguchi Hiroyuki Jinnouchi Takunori Tsukui Yusuke Watanabe Masashi Hatori Kei Yamamoto Masaru Seguchi Hideo Fujita Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction Journal of Clinical Medicine percutaneous coronary intervention acute myocardial infarction appetite major adverse cardiac events |
| title | Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction |
| title_full | Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction |
| title_fullStr | Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction |
| title_full_unstemmed | Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction |
| title_short | Appetite Predicts Long-Term Clinical Outcomes in Patients with Acute Myocardial Infarction |
| title_sort | appetite predicts long term clinical outcomes in patients with acute myocardial infarction |
| topic | percutaneous coronary intervention acute myocardial infarction appetite major adverse cardiac events |
| url | https://www.mdpi.com/2077-0383/12/19/6134 |
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