New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?
Current knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/4/593 |
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| author | Nerea M. Molina Alberto Sola-Leyva Maria Jose Saez-Lara Julio Plaza-Diaz Aleksandra Tubić-Pavlović Barbara Romero Ana Clavero Juan Mozas-Moreno Juan Fontes Signe Altmäe |
| author_facet | Nerea M. Molina Alberto Sola-Leyva Maria Jose Saez-Lara Julio Plaza-Diaz Aleksandra Tubić-Pavlović Barbara Romero Ana Clavero Juan Mozas-Moreno Juan Fontes Signe Altmäe |
| author_sort | Nerea M. Molina |
| collection | DOAJ |
| description | Current knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, that microbial dysbiosis could be associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, and infertility. Treatments using antibiotics and probiotics and/or prebiotics for endometrial microbial dysbiosis are being applied. Nevertheless there is no unified protocol for assessing the endometrial dysbiosis and no optimal treatment protocol for the established dysbiosis. With this review we outline the microbes (mostly bacteria) identified in the endometrial microbiome studies, the current treatments offered for bacterial dysbiosis in the clinical setting, and the future possibilities such as pro- and prebiotics and microbial transplants for modifying uterine microbial composition. |
| first_indexed | 2024-03-10T20:32:01Z |
| format | Article |
| id | doaj.art-844c1c3364194607959958d7707676ad |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T20:32:01Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-844c1c3364194607959958d7707676ad2023-11-19T21:21:10ZengMDPI AGBiomolecules2218-273X2020-04-0110459310.3390/biom10040593New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future?Nerea M. Molina0Alberto Sola-Leyva1Maria Jose Saez-Lara2Julio Plaza-Diaz3Aleksandra Tubić-Pavlović4Barbara Romero5Ana Clavero6Juan Mozas-Moreno7Juan Fontes8Signe Altmäe9Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, 18071 Granada, SpainDepartment of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, 18071 Granada, SpainDepartment of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, 18071 Granada, SpainInstituto de Investigación Biosanitaria ibs.GRANADA, 18014 Granada, SpainClinic of Gynecology and Obstetrics, Clinical Center Niš, 18000 Niš, SerbiaInstituto de Investigación Biosanitaria ibs.GRANADA, 18014 Granada, SpainInstituto de Investigación Biosanitaria ibs.GRANADA, 18014 Granada, SpainInstituto de Investigación Biosanitaria ibs.GRANADA, 18014 Granada, SpainInstituto de Investigación Biosanitaria ibs.GRANADA, 18014 Granada, SpainDepartment of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, 18071 Granada, SpainCurrent knowledge suggests that the uterus harbours its own microbiota, where the microbes could influence the uterine functions in health and disease; however, the core uterine microbial composition and the host-microbial relationships remain to be fully elucidated. Different studies are indicating, based on next-generation sequencing techniques, that microbial dysbiosis could be associated with several gynaecological disorders, such as endometriosis, chronic endometritis, dysfunctional menstrual bleeding, endometrial cancer, and infertility. Treatments using antibiotics and probiotics and/or prebiotics for endometrial microbial dysbiosis are being applied. Nevertheless there is no unified protocol for assessing the endometrial dysbiosis and no optimal treatment protocol for the established dysbiosis. With this review we outline the microbes (mostly bacteria) identified in the endometrial microbiome studies, the current treatments offered for bacterial dysbiosis in the clinical setting, and the future possibilities such as pro- and prebiotics and microbial transplants for modifying uterine microbial composition.https://www.mdpi.com/2218-273X/10/4/593antibioticschronic endometritisendometriosisendometriummicrobiomemicrobiota |
| spellingShingle | Nerea M. Molina Alberto Sola-Leyva Maria Jose Saez-Lara Julio Plaza-Diaz Aleksandra Tubić-Pavlović Barbara Romero Ana Clavero Juan Mozas-Moreno Juan Fontes Signe Altmäe New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? Biomolecules antibiotics chronic endometritis endometriosis endometrium microbiome microbiota |
| title | New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? |
| title_full | New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? |
| title_fullStr | New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? |
| title_full_unstemmed | New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? |
| title_short | New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? |
| title_sort | new opportunities for endometrial health by modifying uterine microbial composition present or future |
| topic | antibiotics chronic endometritis endometriosis endometrium microbiome microbiota |
| url | https://www.mdpi.com/2218-273X/10/4/593 |
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