The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type
Hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular and cholangiocarcinoma are the most common cancers of the liver. In this study, our first aim is to evaluate the relationship between prognosis and clinicopathological parameters. The second aim involves investiga...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2020-07-01
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| Series: | Polish Journal of Pathology |
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| Online Access: | https://www.termedia.pl/The-prognostic-relationship-between-histopathological-and-immunohistochemical-features-of-hepatocellular-carcinoma-intrahepatic-cholangiocarcinoma-and-mixed-type,55,41201,1,1.html |
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| author | Fatmagül Çabuk Nuray Başsüllü İlknur Türkmen Murat Dayangaç Murat Akyıldız Yıldıray Yüzer Yaman Tokat Gülen Doğusoy |
| author_facet | Fatmagül Çabuk Nuray Başsüllü İlknur Türkmen Murat Dayangaç Murat Akyıldız Yıldıray Yüzer Yaman Tokat Gülen Doğusoy |
| author_sort | Fatmagül Çabuk |
| collection | DOAJ |
| description | Hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular and cholangiocarcinoma are the most common cancers of the liver. In this study, our first aim is to evaluate the relationship between prognosis and clinicopathological parameters. The second aim involves investigating the need for immunohistochemical staining and patterns of tumours to differentiate between them.
Sixty-one cases were included in this study. For IHC, we used Hep par-1, CK7, CK19, CD56 and p53 staining, and the patterns of tumours were evaluated in haematoyxylin-eosin sections.
No significant differences were found in Kaplan-Meier life analysis between the tumour types and OS and DFS values, but these values were greater in HCC than in ICC. There were no relationships between clinicopathologic parameters and OS and DFS. Although the multifocality, stage and grade of tumour were higher in HCC than in ICC, the perineural invasion and lymph node metastasis were more common in ICC than in HCC.
The diagnosis was changed in 4 cases, from HCC to ICC in one case and to combined type in 3 cases after IHC. Pathologist should be alert to mixed patterns in terms of diagnosis and IHC, because it helps differential diagnosis in these cases. |
| first_indexed | 2024-12-20T19:07:02Z |
| format | Article |
| id | doaj.art-844d939523414813b17006b04a213dfc |
| institution | Directory Open Access Journal |
| issn | 1233-9687 2084-9869 |
| language | English |
| last_indexed | 2024-12-20T19:07:02Z |
| publishDate | 2020-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Pathology |
| spelling | doaj.art-844d939523414813b17006b04a213dfc2022-12-21T19:29:16ZengTermedia Publishing HousePolish Journal of Pathology1233-96872084-98692020-07-01712798610.5114/pjp.2020.9701541201The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed typeFatmagül ÇabukNuray Başsüllüİlknur TürkmenMurat DayangaçMurat AkyıldızYıldıray YüzerYaman TokatGülen DoğusoyHepatocellular carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular and cholangiocarcinoma are the most common cancers of the liver. In this study, our first aim is to evaluate the relationship between prognosis and clinicopathological parameters. The second aim involves investigating the need for immunohistochemical staining and patterns of tumours to differentiate between them. Sixty-one cases were included in this study. For IHC, we used Hep par-1, CK7, CK19, CD56 and p53 staining, and the patterns of tumours were evaluated in haematoyxylin-eosin sections. No significant differences were found in Kaplan-Meier life analysis between the tumour types and OS and DFS values, but these values were greater in HCC than in ICC. There were no relationships between clinicopathologic parameters and OS and DFS. Although the multifocality, stage and grade of tumour were higher in HCC than in ICC, the perineural invasion and lymph node metastasis were more common in ICC than in HCC. The diagnosis was changed in 4 cases, from HCC to ICC in one case and to combined type in 3 cases after IHC. Pathologist should be alert to mixed patterns in terms of diagnosis and IHC, because it helps differential diagnosis in these cases.https://www.termedia.pl/The-prognostic-relationship-between-histopathological-and-immunohistochemical-features-of-hepatocellular-carcinoma-intrahepatic-cholangiocarcinoma-and-mixed-type,55,41201,1,1.htmlhepatocellular carcinoma liver neoplasms cholangiocarcinoma risk factors. |
| spellingShingle | Fatmagül Çabuk Nuray Başsüllü İlknur Türkmen Murat Dayangaç Murat Akyıldız Yıldıray Yüzer Yaman Tokat Gülen Doğusoy The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type Polish Journal of Pathology hepatocellular carcinoma liver neoplasms cholangiocarcinoma risk factors. |
| title | The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type |
| title_full | The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type |
| title_fullStr | The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type |
| title_full_unstemmed | The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type |
| title_short | The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type |
| title_sort | prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma intrahepatic cholangiocarcinoma and mixed type |
| topic | hepatocellular carcinoma liver neoplasms cholangiocarcinoma risk factors. |
| url | https://www.termedia.pl/The-prognostic-relationship-between-histopathological-and-immunohistochemical-features-of-hepatocellular-carcinoma-intrahepatic-cholangiocarcinoma-and-mixed-type,55,41201,1,1.html |
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